OMIA:002712-9031 : Biopharming, IgG1-related in Gallus gallus (chicken)

Categories: Immune system phene

Links to MONDO diseases: No links.

Mendelian trait/disorder: unknown

Considered a defect: no

Species-specific description: Park et al. (2023) "generated genome-edited chickens that synthesize human IgG1 Fc in the liver and secrete α-2,6 sialylated and low-fucosylated human IgG1 Fc (rhIgG1 Fc) into serum and egg yolk." This study involves genetically modified organisms (GMO).

Genetic engineering: Yes - variants have been created artificially, e.g. by genetic engineering or gene editing
Have human generated variants been created, e.g. through genetic engineering and gene editing

Cite this entry

Nicholas, F. W., Tammen, I., & Sydney Informatics Hub. (2023). OMIA:002712-9031: Online Mendelian Inheritance in Animals (OMIA) [dataset]. https://omia.org/. https://doi.org/10.25910/2AMR-PV70

Reference

2023 Park, J.S., Choi, H.J., Jung, K.M., Lee, K.Y., Shim, J.H., Park, K.J., Kim, Y.M., Han, J.Y. :
Production of recombinant human IgG1 Fc with beneficial N-glycosylation pattern for anti-inflammatory activity using genome-edited chickens. Commun Biol 6:589, 2023. Pubmed reference: 37264071. DOI: 10.1038/s42003-023-04937-5.

Edit History


  • Created by Imke Tammen2 on 04 Jun 2023
  • Changed by Imke Tammen2 on 04 Jun 2023
  • Changed by Imke Tammen2 on 18 Dec 2023