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OMIA:002771-9615 : Lissencephaly, generic in Canis lupus familiaris (dog)

In other species: domestic cat , taurine cattle , goat

Categories: Nervous system phene

Links to MONDO diseases: No links.

Mendelian trait/disorder: unknown

Considered a defect: yes

Cross-species summary: Lissencephalic brains (brains with a smooth cerebral cortex) are normal in many species (including some small rodents and small primates). The disease lissencephaly refers to a group of brain conditions in species that normally have gyrencephalic brains, in which the cerebral cortex is smooth due to defective neuronal migration during embryonic development resulting in a reduction or absence of sulci and gyri. Various non-genetic and genetic factors have been reported to cause lissencephaly.

Species-specific description: See also OMIA:001867-9615 : Lissencephaly and cerebellar hypoplasia, RELN-related in Canis lupus familiaris

Genetic engineering: Unknown
Have human generated variants been created, e.g. through genetic engineering and gene editing

Breeds: Australian Kelpie (Dog) (VBO_0200090), Lhasa Apso (Dog) (VBO_0200824), Mixed Breed (Dog) (VBO_0200902), Pekingese (Dog) (VBO_0200994), Shih Tzu (Dog) (VBO_0201223).
Breeds in which the phene has been documented. For breeds in which a likely causal variant has been documented, see the variant table below

Cite this entry

Nicholas, F. W., Tammen, I., & Sydney Informatics Hub. (2024). OMIA:002771-9615: Online Mendelian Inheritance in Animals (OMIA) [dataset]. https://omia.org/. https://doi.org/10.25910/2AMR-PV70

References

Note: the references are listed in reverse chronological order (from the most recent year to the earliest year), and alphabetically by first author within a year.

2020 Rodríguez-Sánchez, D.N., Pinto, G.B.A., Thomé, E.F., Machado, V.M.V., Amorim, R.M. :
Lissencephaly in Shih Tzu dogs. Acta Vet Scand 62:32, 2020. Pubmed reference: 32563254. DOI: 10.1186/s13028-020-00528-0.
2017 Shimbo, G., Tagawa, M., Oohashi, E., Yanagawa, M., Miyahara, K. :
Lissencephaly in a Pekingese. J Vet Med Sci 79:1694-1697, 2017. Pubmed reference: 28819088. DOI: 10.1292/jvms.17-0271.
2016 Fraser, A.R., le Chevoir, M.A., Long, S.N. :
Lissencephaly in an adult Australian Kelpie. Aust Vet J 94:107-10, 2016. Pubmed reference: 27021891. DOI: 10.1111/avj.12423.
2011 Lee, K.I., Lim, C.Y., Kang, B.T., Park, H.M. :
Clinical and MRI findings of lissencephaly in a mixed breed dog. J Vet Med Sci 73:1385-8, 2011. Pubmed reference: 21685716.
2002 Saito, M., Sharp, N.J., Kortz, G.D., de Lahunta, A., Leventer, R.J., Tokuriki, M., Thrall, D.E. :
Magnetic resonance imaging features of lissencephaly in 2 Lhasa Apsos. Vet Radiol Ultrasound 43:331-7, 2002. Pubmed reference: 12174995.
1976 Greene, C.E., Vandevelde, M., Braund, K. :
Lissencephaly in two Lhasa Apso dogs. J Am Vet Med Assoc 169:405-10, 1976. Pubmed reference: 956022.
Zaki, F.A. :
Lissencephaly in Lhasa Apso dogs. J Am Vet Med Assoc 169:1165, 1168, 1976. Pubmed reference: 1033927.

Edit History


  • Created by Imke Tammen2 on 22 Sep 2023
  • Changed by Imke Tammen2 on 22 Sep 2023
  • Changed by Imke Tammen2 on 08 Feb 2024