OMIA:002820-310915 : DND1 deficiency in Pangasianodon hypophthalmus (striped catfish) |
Categories: Reproductive system phene
Possibly relevant human trait(s) and/or gene(s) (MIM number): 609385 (gene)
Links to MONDO diseases: No links.
Mendelian trait/disorder: yes
Considered a defect: yes
Key variant known: yes
Year key variant first reported: 2024
Species-specific description: Booncherd et al. (2024) "aimed to develop CRISPR/Cas9 mediated dead-end 1 (dnd1) knockout techniques for striped catfish (Pangasianodon hypophthalmus). ... CRISPR/Cas 9 targeting dnd1 knockout at the upstream sequences of start codon was achieved, which resulted in the downregulation of dnd1 and lowered PGC number." This study involves genetically modified organisms (GMO).
Genetic engineering:
Yes - variants have been created artificially, e.g. by genetic engineering or gene editing
Have human generated variants been created, e.g. through genetic engineering and gene editing
Associated gene:
| Symbol | Description | Species | Chr | Location | OMIA gene details page | Other Links |
|---|---|---|---|---|---|---|
| dnd1 | DND microRNA-mediated repression inhibitor 1 | Pangasianodon hypophthalmus | 9 | NC_069718.1 (9048878..9062057) | dnd1 | Homologene, Ensembl , NCBI gene |
Cite this entry
Nicholas, F. W., Tammen, I., & Sydney Informatics Hub. (2024). OMIA:002820-310915: Online Mendelian Inheritance in Animals (OMIA) [dataset]. https://omia.org/. https://doi.org/10.25910/2AMR-PV70
Reference
| 2024 | Booncherd, K., Sreebun, S., Pasomboon, P., Boonanuntanasarn, S. : |
| Effects of CRISPR/Cas9-mediated dnd1 knockout impairs gonadal development in striped catfish. Animal 18:S1751-7311(23)00356-7:101039, 2024. Pubmed reference: 38103430. DOI: 10.1016/j.animal.2023.101039. |
Edit History
- Created by Imke Tammen2 on 25 Jan 2024