In other species: mangrove rivulus , corn snake

Categories: Skeleton phene (incl. short stature & teeth) , Integument (skin) phene , Limbs / fins / digit / tail phene

Links to possible relevant human trait(s) and/or gene(s) in OMIM: 606603 (gene) , 614940 (trait) , 614941 (trait)

Single-gene trait/disorder: yes

Disease-related: unknown

Key variant known: no

Molecular basis: Saud et al. (2025) investigated a novel ENU-mutated mangrove killifish line with reduced fin development and identified a likely causal missense variant in the edaradd gene in a highly conserved C-terminal death domain (see OMIA:002887-37003 for details) and confirmed the functional effect by creating edaradd CRISPR knock out Arabian killifish. This study involves gene edited or genetically modified organisms (GMO).

Genetic engineering: Yes - variants have been created artificially, e.g. by genetic engineering or gene editing
Have human generated variants been created, e.g. through genetic engineering and gene editing

Associated gene: