Categories: Mortality / aging (incl. embryonic lethal)

Single-gene trait/disorder: unknown

Disease-related: yes

Species summary: Stoffel et al. (2024) "combined genomic, fitness, and life-history data from 5,925 wild Soay sheep ... to explore the impact of embryonic lethal mutations and their evolutionary dynamics. [The authors] searched for haplotypes that in their homozygous state are unusually rare in the offspring of known carrier parents and found three putatively semi-lethal haplotypes [SEL05, SEL07 and SEL18] with 27%–46% fewer homozygous offspring than expected.

Breed: Soay (Sheep) (VBO_0001605).
Breeds in which the phene or likely causal variants have been documented. If a likely causal variant has been documented, see variant-specific breed information in the variant table. (Breed information may be incomplete).