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OMIA:002915-10036 : Apolipoprotein C-II deficiency in Mesocricetus auratus (golden hamster)

Categories: Homeostasis / metabolism phene

Links to possible relevant human trait(s) and/or gene(s) in OMIM: 608083 (gene) , 207750 ()

Single-gene trait/disorder: yes

Disease-related: unknown

Key variant known: no

Species summary: Shen et al. (2024): Acute seizure models were established both in vivo and ex vivo using wild-type and Apolipoprotein C2 knockout (Apoc2−/−) hamsters. ... Hypertriglyceridemic Apoc2−/− hamsters exhibited reduced seizure frequency and decreased cortical neuron excitability." This study involves gene edited or genetically modified organisms (GMO).

Species-specific name: Hypertriglyceridemia

Genetic engineering: Yes - variants have been created artificially, e.g. by genetic engineering or gene editing
Have human generated variants been created, e.g. through genetic engineering and gene editing

Associated gene:

Symbol Description Species Chr Location OMIA gene details page Other Links
Apoc2 apolipoprotein C2 Mesocricetus auratus NW_024429216.1 (10879289..10883409) Apoc2 Ensembl, NCBI gene

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Cite this entry

Nicholas, F. W., Tammen, I., & Sydney Informatics Hub. (2025). OMIA:002915-10036: Online Mendelian Inheritance in Animals (OMIA) [dataset]. https://omia.org/. https://doi.org/10.25910/2AMR-PV70

References

Note: the references are listed in reverse chronological order (from the most recent year to the earliest year), and alphabetically by first author within a year.

2024 Shen, Q., Liu, N., Jiang, Y., Liu, L., Hou, X. :
Decreased neuronal excitability in hypertriglyceridemia hamsters with acute seizures. Front Neurol 15:1500737, 2024. Pubmed reference: 39811454. DOI: 10.3389/fneur.2024.1500737.
2020 Gao, M., Yang, C., Wang, X., Guo, M., Yang, L., Gao, S., Zhang, X., Ruan, G., Li, X., Tian, W., Lu, G., Dong, X., Ma, S., Li, W., Wang, Y., Zhu, H., He, J., Yang, H., Liu, G., Xian, X. :
ApoC2 deficiency elicits severe hypertriglyceridemia and spontaneous atherosclerosis: A rodent model rescued from neonatal death. Metabolism 109:154296, 2020. Pubmed reference: 32562799. DOI: 10.1016/j.metabol.2020.154296.

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  • Created by Imke Tammen2 on 22 Jan 2025