OMIA:003005-9541 : Infertility, ZP1-related in Macaca fascicularis (crab-eating macaque) |
Categories: Reproductive system phene
Links to possible relevant human trait(s) and/or gene(s) in OMIM: 195000 (gene) , 615774 (trait)
Links to relevant human diseases in MONDO:
Single-gene trait/disorder: yes
Disease-related: yes
Key variant known: yes
Year key variant first reported: 2025
Species summary: Meng et al. (2025): "CRISPR/Cas9-mediated genome editing was employed to generate two ZP1-edited cynomolgus macaques (Macaca fascicularis), designated #ZP1-1 (male) and #ZP1-2 (female). Following sexual maturation, oocytes retrieved from #ZP1-2 through superovulation exhibited a marked increase in zona pellucida-deficient oocytes and a significant reduction in maturation rates compared to controls." This phene includes references to studies involving gene edited or genetically modified organisms (GMO).
Genetic engineering:
Yes - variants have been created artificially, e.g. by genetic engineering or gene editing
Have human generated variants been created, e.g. through genetic engineering and gene editing
Associated gene:
| Symbol | Description | Species | Chr | Location | OMIA gene details page | Other Links |
|---|---|---|---|---|---|---|
| ZP1 | zona pellucida glycoprotein 1 | Macaca fascicularis | 14 | NC_088388.1 (13403428..13394887) | ZP1 | Ensembl, NCBI gene |
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Cite this entry
Nicholas, F. W., Tammen, I., & Sydney Informatics Hub. (2025). OMIA:003005-9541: Online Mendelian Inheritance in Animals (OMIA) [dataset]. https://omia.org/. https://doi.org/10.25910/2AMR-PV70
Reference
| 2025 | Meng, W., Liu, B.Z., Huang, D., Fan, Y.T., Xiong, C.G., Zhang, Y.T., Zhao, L.L., Guo, Y.L., Lai, M.H., Zhao, X.Y., Li, Y.Q., Zhao, S.K., Zeng, J.T., Liu, C.H., Liu, J.L., Ding, C.H., Yang, S.H. : |
| Abnormal zona pellucida and follicular development in ZP1-mutant macaques. Zool Res 46:2095-8137(2025)05-1093-15:1093-1107, 2025. Pubmed reference: 40923306. DOI: 10.24272/j.issn.2095-8137.2024.415. |
Edit History
- Created by Imke Tammen2 on 10 Sep 2025
- Changed by Imke Tammen2 on 10 Sep 2025