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OMIA:000168-9913 : Cataract, generic in Bos taurus (taurine cattle)

In other species: chicken , grivet , crab-eating macaque , dog , giant panda , domestic ferret , domestic cat , lion , ass (donkey) , horse , sheep , rabbit , domestic guinea pig , degu , bald eagle , green monkey

Categories: Vision / eye phene

Links to MONDO diseases: No links.

Mendelian trait/disorder: yes

Mode of inheritance: Autosomal recessive

Considered a defect: yes

Key variant known: no

Key variant is published: no

Cross-species summary: Opacity of the lens of the eye.

Inheritance: Detlefson and Yapp (1920) reported convincing evidence of single-locus autosomal recessive inheritance in US Holsteins, involving 70 offspring from the test mating of a bull and one of his sons to daughters of the bull. Gregory et al. (1943) reported equally convincing data involving what appeared to be the same defect in US Jerseys. In contrast, Ashton et al. (1977) discounted hereditary involvement in "two outbreaks of congenital cataract in [Holstein-Friesian] dairy herds" in the UK.

Genetic engineering: Unknown
Have human generated variants been created, e.g. through genetic engineering and gene editing

Breeds: Holstein (black and white) (Cattle) (VBO_0000237), Jersey (Cattle) (VBO_0000250).
Breeds in which the phene has been documented. For breeds in which a likely causal variant has been documented, see the variant table below

Cite this entry

Nicholas, F. W., Tammen, I., & Sydney Informatics Hub. (2012). OMIA:000168-9913: Online Mendelian Inheritance in Animals (OMIA) [dataset]. https://omia.org/. https://doi.org/10.25910/2AMR-PV70

References

Note: the references are listed in reverse chronological order (from the most recent year to the earliest year), and alphabetically by first author within a year.

2024 Mee, J.F., Murphy, D., Curran, M. :
Bovine congenital defects recorded by veterinary practitioners. Reprod Domest Anim 59:e14501, 2024. Pubmed reference: 37975255. DOI: 10.1111/rda.14501.
2023 Clifford, S.C. :
Bilateral cataract development in Holstein heifer calves. Can Vet J 64:181-183, 2023. Pubmed reference: 36733650.
2014 Krump, L., O'Grady, L., Lorenz, I., Grimes, T. :
Congenital cataracts in an Ayrshire herd: a herd case report. Ir Vet J 67:2, 2014. Pubmed reference: 24460638. DOI: 10.1186/2046-0481-67-2.
2012 Hässig, M., Jud, F., Spiess, B. :
[Increased occurrence of nuclear cataract in the calf after erection of a mobile phone base station]. Schweiz Arch Tierheilkd 154:82-6, 2012. Pubmed reference: 22287140. DOI: 10.1024/0036-7281/a000300.
2009 Hässig, M., Jud, F., Naegeli, H., Kupper, J., Spiess, B.M. :
Prevalence of nuclear cataract in Swiss veal calves and its possible association with mobile telephone antenna base stations. Schweiz Arch Tierheilkd 151:471-8, 2009. Pubmed reference: 19780007. DOI: 10.1024/0036-7281.151.10.471.
2008 Hurley, S. :
Blind but healthy calves. Vet Rec 163:579, 2008. Pubmed reference: 18997190.
Manser, CE. :
Congenital cataract in calves. Vet Rec 163:668, 2008. Pubmed reference: 19043100.
1990 France, M.P., Shaw, J.M. :
Blood glucose, calcium and urea in cows from a herd with congenital nuclear cataract Veterinary Record 126:484-485, 1990.
1987 France, M.P., Barlow, R.M., Barnett, K.C. :
Congenital nuclear cataracts in calves. Vet Rec 121:528, 1987. Pubmed reference: 3433642.
Kaswan, RL., Collins, LG., Blue, JL., Martin, CL. :
Multiple hereditary ocular anomalies in a herd of cattle. J Am Vet Med Assoc 191:97-9, 1987. Pubmed reference: 3112051.
1984 Gelatt, KN., Das, ND. :
Animal models for inherited cataracts: a review. Curr Eye Res 3:765-78, 1984. Pubmed reference: 6734258.
1981 Holmes, J.H., Humphrey, J.D., Walton, E.A., O'Shea, J.D. :
Cataracts, goitre and infertility in cattle grazed on an exclusive diet of Leucaena leucocephala. Aust Vet J 57:257-61, 1981. Pubmed reference: 7316890.
1977 Ashton, N., Barnett, K.C., Clay, C.E., Clegg, F.C. :
Congenital nuclear cataracts in cattle. Vet Rec 100:505-8, 1977. Pubmed reference: 878267.
1975 Bhargava, A.K., Dhablania, D.C., Tyagi, R.P.S. :
Congenital cataract in cattle Indian Veterinary Journal 52:478-479 , 1975.
1971 Gelatt, K.N. :
Cataracts in cattle. J Am Vet Med Assoc 159:195-200, 1971. Pubmed reference: 5106050.
1960 Carter, A.H. :
An inherited blindness (cataract) in cattle Proceedings of the New Zealand Society of Animal Production 20:108 only, 1960.
1951 Saunders, L.Z., Fincher, M.G. :
Hereditary multiple eye defects in grade Jersey cows Cornell Veterinarian 41:351-366, 1951. Pubmed reference: 14887336.
1943 Gregory, P.W., Mead, S.W., Regan, W.M. :
A congenital hereditary eye defect of cattle Journal of Heredity 34:125-128, 1943.
1920 Detlefson, J.A., Yapp, W.W. :
The inheritance of congenital cataract in cattle American Naturalist 54:277-280, 1920.
1919 Smith, C.P. :
Hereditary cataract in calves American Journal of Ophthalmology 2:681-682, 1919.

Edit History


  • Created by Frank Nicholas on 16 Oct 2010
  • Changed by Frank Nicholas on 24 Aug 2012