OMIA 000437 : Haemophilia A

Possible human homologues (MIM numbers): 306700 (trait) , 300841 (gene)

Cross-species summary: Also called factor VIII deficiency. Impaired coagulability of the blood, with a consequential strong tendency to bleed, due to a deficiency of clotting factor VIII. Since the gene for this factor is located on the X chromosome, the disorder is expected to be X-linked. As with haemophilia B, this expectation has been confirmed in all species of mammal in which the disorder has been reported. In humans, there are hundreds of different mutations that give rise to haemophilia A. In domesticated animals, the disorder has been reported in a large range of species.

Species in which this phene is found:
crab-eating macaque (Macaca fascicularis)
dog (Canis lupus familiaris)
domestic cat (Felis catus)
horse (Equus caballus)
pig (Sus scrofa)
cattle (Bos taurus)
sheep (Ovis aries)

Edit History


  • Created by Frank Nicholas on 04 Nov 2010
  • Changed by Frank Nicholas on 21 May 2012
  • Changed by Frank Nicholas on 03 Dec 2012
  • Changed by Frank Nicholas on 19 Jan 2016
  • Changed by Frank Nicholas on 19 Nov 2018
  • Changed by Imke Tammen2 on 21 Jan 2022
  • Changed by Imke Tammen2 on 18 Mar 2022