OMIA:000439-10036 : Hair, long in Mesocricetus auratus
In other species: domestic cat , goat , dog , rabbit , cattle , ass , domestic guinea pig , llama , Arabian camel , sheep , alpaca , domestic yak
Categories: Integument (skin) phene
Possibly relevant human trait(s) and/or gene(s)s (MIM numbers): 190330 (trait) , 165190 (gene)
Links to MONDO diseases: No links.
Mendelian trait/disorder: yes
Mode of inheritance: Autosomal recessive
Considered a defect: yes
Key variant known: yes
Year key variant first reported: 2014
Cross-species summary: Long hair = angora
Inheritance: Autosomal recessive (Fukuta et al., 1993)
Molecular basis: Yoshizawa et al. (2016) "detected a c.546delG of Fgf5 . . . that might lead to truncation resulting from a frame shift in FGF5 (p.Arg184GlyfsX6). Additionally, [homozygosity for this variant] . . . was only detected in long-haired . . . progenies, and all homozygous wild and heterozygous . . . individuals showed normal hair length. . . . To our knowledge, this report is the first to present the sexual dimorphism of hair length caused by the Fgf5 mutation."
|Symbol||Description||Species||Chr||Location||OMIA gene details page||Other Links|
|Fgf5||fibroblast growth factor 5||Mesocricetus auratus||NW_024429190.1 (72569391..72591933)||Fgf5||Homologene, Ensembl , NCBI gene|
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WARNING! Inclusion of a variant in this table does not automatically mean that it should be used for DNA testing. Anyone contemplating the use of any of these variants for DNA testing should examine critically the relevant evidence (especially in breeds other than the breed in which the variant was first described). If it is decided to proceed, the location and orientation of the variant sequence should be checked very carefully.
Since October 2021, OMIA includes a semiautomated lift-over pipeline to facilitate updates of genomic positions to a recent reference genome position. These changes to genomic positions are not always reflected in the ‘acknowledgements’ or ‘verbal description’ fields in this table.
|OMIA Variant ID||Breed(s)||Variant Phenotype||Gene||Allele||Type of Variant||Source of Genetic Variant||Reference Sequence||Chr.||g. or m.||c. or n.||p.||Verbal Description||EVA ID||Inferred EVA rsID||Year Published||PubMed ID(s)||Acknowledgements|
|559||Hair, long||Fgf5||deletion, small (<=20)||Naturally occurring variant||c.546delG||p.(R184GfsX6)||2015||26481120|
Note: the references are listed in reverse chronological order (from the most recent year to the earliest year), and alphabetically by first author within a year.
|2016||Yoshizawa, Y., Wada, K., Shimoi, G., Kameyama, Y., Wakabayashi, Y., Fukuta, K., Hashizume, R. :|
|Erratum to: A 1-bp deletion in Fgf5 causes male-dominant long hair in the Syrian hamster. Mamm Genome 27:98, 2016. Pubmed reference: 26689206 . DOI: 10.1007/s00335-015-9617-4.|
|2015||Yoshizawa, Y., Wada, K., Shimoi, G., Shiomi, G., Kameyama, Y., Wakabayashi, Y., Fukuta, K., Hashizume, R. :|
|A 1-bp deletion in Fgf5 causes male-dominant long hair in the Syrian hamster. Mamm Genome 26:630-7, 2015. Pubmed reference: 26481120 . DOI: 10.1007/s00335-015-9608-5.|
|1999||Mezick, J.A., Gendimenico, G.J., Liebel, F.T., Stenn, K.S. :|
|Androgen-induced delay of hair growth in the golden Syrian hamster. Br J Dermatol 140:1100-4, 1999. Pubmed reference: 10354077 .|
|1993||Fukuta, K., Sakamoto, K., Hashizume, R., Mannen, H., Goto, N. :|
|Establishment of Inbred Strain of Long-Haired Golden Hamster Experimental Animals 42:343-347, 1993. Pubmed reference: 8354355 .|
|1978||Robinson, R., Peterson, J.S., Yoon, C.H. :|
|Linkage group III in the Syrian hamster: linkage between white band and long hair. J Hered 69:199, 1978. Pubmed reference: 731009 .|
|1975||Robinson, R. :|
|Linkage of white band and long hair in the Syrian hamster. J Hered 66:312, 1975. Pubmed reference: 1184955 .|
|1973||Schimke, D.J., Nixon, C.W., Connelly, M.E. :|
|Long hair : A new mutation in the Syrian hamster Journal of Heredity 64:236-237, 1973. Pubmed reference: 4766213 .|
- Created by Frank Nicholas on 06 Sep 2005
- Changed by Frank Nicholas on 15 Sep 2016