OMIA:000439-9940 : Hair, long in Ovis aries (sheep)
Categories: Integument (skin) phene
Links to MONDO diseases:
Mendelian trait/disorder: yes
Considered a defect: no
Key variant known: no
Cross-species summary: Long hair = angora
Species-specific description: This phene includes references to studies involving genetically modified organisms (GMO).
Hu et al. (2017): "generated 3 FGF5 knockout sheep via the 1-step clustered regularly interspaced short palindromic repeat (CRISPR)/Cas9 system. Sequencing analysis confirmed that mutations in the FGF5 gene existed in all germ lines of 3 founders: besides the intact sequence, 3 kinds of deletions in the FGF5 gene (including 5, 13, and 33 bp) were detected. The changes in the primary and senior structure of the FGF5 protein due to the 3 deletions in founders suggested that the FGF5 protein was dysfunctional. In addition, the expression level of intact FGF5 mRNA in heterozygous individuals decreased compared with the wild types (P < 0.01). Functionally, we discovered that wool length in founders was significantly longer than in wild types (P < 0.05)."
Zhang et al. (2020): "generated five FGF5-knockout Dorper sheep by the CRISPR/Cas9 system. The expression level of FGF5 mRNA in knockout (KO) sheep decreased significantly, and all FGF5 proteins were dysfunctional. The KO sheep displayed a significant increase in fine-wool and active hair-follicle density."
Yes - variants have been created artificially, e.g. by genetic engineering or gene editing
Have human generated variants been created, e.g. through genetic engineering and gene editing
|Symbol||Description||Species||Chr||Location||OMIA gene details page||Other Links|
|FGF5||fibroblast growth factor 5||Ovis aries||6||NC_056059.1 (95668983..95690859)||FGF5||Homologene, Ensembl , NCBI gene|
Cite this entry
Note: the references are listed in reverse chronological order (from the most recent year to the earliest year), and alphabetically by first author within a year.
|2023||Chen, M., Lian, D., Li, Y., Zhao, Y., Xu, X., Liu, Z., Zhang, J., Zhang, X., Wu, S., Qi, S., Deng, S., Yu, K., Lian, Z. :|
|Global long noncoding RNA expression profiling of MSTN and FGF5 double-knockout sheep reveals the key gatekeepers of skeletal muscle development. DNA Cell Biol 42:163-175, 2023. Pubmed reference: 36917699. DOI: 10.1089/dna.2022.0574.|
|Chen, M., Zhao, Y., Li, Y., Chen, T., Zhou, W., Zhang, X., Deng, S., Xu, X., Wu, S., Liu, Z., Qi, S., Wang, L., Li, Y., Yu, K., Lian, Z. :|
|Reproduction and viscera organ characteristics of MSTN and FGF5 dual-gene knockout sheep. Front Vet Sci 10:1119312, 2023. Pubmed reference: 37065235. DOI: 10.3389/fvets.2023.1119312.|
|2020||Zhang, R., Li, Y., Jia, K., Xu, X., Li, Y., Zhao, Y., Zhang, X., Zhang, J., Liu, G., Deng, S., Lian, Z. :|
|Crosstalk between androgen and Wnt/β-catenin leads to changes of wool density in FGF5-knockout sheep. Cell Death Dis 11:407, 2020. Pubmed reference: 32472005. DOI: 10.1038/s41419-020-2622-x.|
|2017||Hu, R., Fan, Z.Y., Wang, B.Y., Deng, S.L., Zhang, X.S., Zhang, J.L., Han, H.B., Lian, Z.X. :|
|RAPID COMMUNICATION: Generation of FGF5 knockout sheep via the CRISPR/Cas9 system. J Anim Sci 95:2019-2024, 2017. Pubmed reference: 28727005. DOI: 10.2527/jas.2017.1503.|
- Created by Imke Tammen2 on 27 Aug 2021
- Changed by Imke Tammen2 on 27 Aug 2021
- Changed by Imke Tammen2 on 15 Nov 2023
- Changed by Imke Tammen2 on 10 Dec 2023