OMIA:000519 : Hypoadrenocorticism

Categories: Endocrine / exocrine gland phene (incl mammary gland)

Possible human homologues (MIM numbers): 240200 (trait) , 240300 (trait)

Links to MONDO diseases: No links.

Cross-species summary: Hypoadrenocorticism, or Addison’s disease, results from insufficient secretion of steroid hormones (glucocorticoids and mineralocorticoids) from the adrenal glands. In primary hypoadrenocorticism the disease is due to changes to the adrenal cortex, while secondary hypoadrenocorticism refers to deficiency of ACTH, produced in the pituitary gland. The disease can be further classified as typical (glucocorticoid and mineralocorticoid deficiency) with typical electrolyte changes or atypical (only glucocorticoid deficiency with no typical electrolyte changes). The atypical cases often progress to become typical.

Species in which this phene is found:
dog (Canis lupus familiaris)
domestic cat (Felis catus)
horse (Equus caballus)
goat (Capra hircus)

Edit History


  • Created by Frank Nicholas on 29 Oct 2008
  • Changed by Imke Tammen2 on 01 Dec 2020
  • Changed by Imke Tammen2 on 08 Dec 2020
  • Changed by Imke Tammen2 on 14 Oct 2022
  • Changed by Imke Tammen2 on 19 May 2023