OMIA:001566-9986 : Rex coat in Oryctolagus cuniculus (rabbit)

In other species: golden hamster , domestic guinea pig

Categories: Integument (skin) phene

Links to possible relevant human trait(s) and/or gene(s) in OMIM: 607365 (gene) , 604379 (trait)

Mendelian trait/disorder: yes

Mode of inheritance: Autosomal recessive

Considered a defect: no

Key variant known: yes

Year key variant first reported: 2011

Species-specific name: French rex; Gillet rex; Franz. Rex

Species-specific symbol: rex; r1

Species-specific description: See Robinson (1958, pp. 298-300).

History: This is the first of three rex mutant phenotypes to be described. As summarised by Diribarne et al. (2011), "In 1919 in the Pays de Loire French region, a mutant phenotype with soft hair was observed by a breeder in a litter of wild gray rabbits. Abbé Gillet, a local priest, considered the trait very fancy and started planning crosses to produce rabbits with this soft hair touching phenotype with guard hair that was no longer than the undercoat."

Mapping: Castle and Nachtsheim (1933) showed that r1 rex is linked to r2 rex (OMIA 002005-9986) with a recombination frequency of 10-12%. These same authors showed that the third type of rex in rabbits, r3 (OMIA 002006-9986), segregates independently of r1 and r2.

Molecular basis: Diribarne et al (2011) showed that the r1 rex hair coat phenotype in rabbits is due to a single nucleotide deletion in exon 9 of the LIPH gene.

Associated gene:

Symbol Description Species Chr Location OMIA gene details page Other Links
LIPH lipase, member H Oryctolagus cuniculus 14 NC_067387.1 (81155289..81266104) LIPH Homologene, Ensembl , NCBI gene


By default, variants are sorted chronologically by year of publication, to provide a historical perspective. Readers can re-sort on any column by clicking on the column header. Click it again to sort in a descending order. To create a multiple-field sort, hold down Shift while clicking on the second, third etc relevant column headers.

WARNING! Inclusion of a variant in this table does not automatically mean that it should be used for DNA testing. Anyone contemplating the use of any of these variants for DNA testing should examine critically the relevant evidence (especially in breeds other than the breed in which the variant was first described). If it is decided to proceed, the location and orientation of the variant sequence should be checked very carefully.

Since October 2021, OMIA includes a semiautomated lift-over pipeline to facilitate updates of genomic positions to a recent reference genome position. These changes to genomic positions are not always reflected in the ‘acknowledgements’ or ‘verbal description’ fields in this table.

OMIA Variant ID Breed(s) Variant Phenotype Gene Allele Type of Variant Source of Genetic Variant Reference Sequence Chr. g. or m. c. or n. p. Verbal Description EVA ID Year Published PubMed ID(s) Acknowledgements
450 Rex coat LIPH deletion, small (<=20) Naturally occurring variant 14 c.1362delA 2011 21552526

Cite this entry

Nicholas, F. W., Tammen, I., & Sydney Informatics Hub. (2016). OMIA:001566-9986: Online Mendelian Inheritance in Animals (OMIA) [dataset].


Note: the references are listed in reverse chronological order (from the most recent year to the earliest year), and alphabetically by first author within a year.

2024 Xie, K., Ning, C., Yang, A., Zhang, Q., Wang, D., Fan, X. :
Resequencing analyses revealed genetic diversity and selection signatures during rabbit breeding and improvement. Genes (Basel) 15:433, 2024. Pubmed reference: 38674368. DOI: 10.3390/genes15040433.
2021 Dorożyńska, K., Maj, D. :
Rabbits - their domestication and molecular genetics of hair coat development and quality. Anim Genet 52:10-20, 2021. Pubmed reference: 33216407. DOI: 10.1111/age.13024.
2018 Chen, Y., Zhao, B., Liu, M., Wang, J., Qiu, X., Zhu, C., Wu, X. :
MicroRNAs Profiling Identifies miR-125a and Its Target Gene Wnt2 in Skins of Different Haired Rabbits. Front Genet 9:628, 2018. Pubmed reference: 30619457. DOI: 10.3389/fgene.2018.00628.
2017 Zhao, B., Chen, Y., Yan, X., Hao, Y., Zhu, J., Weng, Q., Wu, X. :
Gene expression profiling analysis reveals fur development in rex rabbits (Oryctolagus cuniculus). Genome 60:1060-1067, 2017. Pubmed reference: 28850794. DOI: 10.1139/gen-2017-0003.
2016 Leroy, G., Besbes, B., Boettcher, P., Hoffmann, I., Capitan, A., Baumung, R. :
Rare phenotypes in domestic animals: unique resources for multiple applications. Anim Genet 47:141-53, 2016. Pubmed reference: 26662214. DOI: 10.1111/age.12393.
2012 Diribarne, M., Mata, X., Rivière, J., Bouet, S., Vaiman, A., Chapuis, J., Reine, F., Fleurot, R., Auvinet, G., Deretz, S., Allain, D., Schibler, L., Cribiu, E.P., Guérin, G. :
LIPH expression in skin and hair follicles of normal coat and Rex rabbits. PLoS One 7:e30073, 2012. Pubmed reference: 22272275. DOI: 10.1371/journal.pone.0030073.
2011 Chen, S.J., Liu, T., Liu, Y.J., Dong, B., Huang, Y.T., Gu, Z.L. :
Identification of single nucleotide polymorphisms in the CCNA2 gene and its association with wool density in Rex rabbits. Genet Mol Res 10:3365-70, 2011. Pubmed reference: 22095474. DOI: 10.4238/2011.November.4.1.
Diribarne, M., Mata, X., Chantry-Darmon, C., Vaiman, A., Auvinet, G., Bouet, S., Deretz, S., Cribiu, E.P., de Rochambeau, H., Allain, D., Guérin, G. :
A deletion in exon 9 of the LIPH gene is responsible for the rex hair coat phenotype in rabbits (Oryctolagus cuniculus). PLoS One 6:e19281, 2011. Pubmed reference: 21552526. DOI: 10.1371/journal.pone.0019281.
1958 Robinson, R. :
Genetic studies of the rabbit. Bibliographia Genetica 17:229–558, 1958.
1933 Castle, WE., Nachtsheim, H. :
Linkage interrelations of three genes for rex (short) coat in the rabbit. Proc Natl Acad Sci U S A 19:1006-11, 1933. Pubmed reference: 16587815.
1929 Castle, W.E. :
The rex rabbit Journal of Heredity 20:193-199, 1929.

Edit History

  • Created by Frank Nicholas on 27 May 2011
  • Changed by Frank Nicholas on 07 Sep 2011
  • Changed by Frank Nicholas on 09 Dec 2011
  • Changed by Frank Nicholas on 03 May 2016