OMIA:001733-9615 : Lymphoma, generic in Canis lupus familiaris (dog)

In other species: domestic cat , horse , western hognose snake , brown howler monkey

Categories: Neoplasm

Mendelian trait/disorder: unknown

Considered a defect: yes

Mapping: Soh et al. (2023) investigated pedigree information from "83,000 Border Collies, with 71 identified lymphoma cases. ... GWAS analysis "identified regions on chromosomes 18 and 27 that harbour cancer-related genes as prime candidates for lymphoma susceptibility, warranting further investigation."

Breeds: Border Collie (Dog) (VBO_0200193), Dachshund, Miniature (Dog) (VBO_0200408), Doberman Pinscher (Dog) (VBO_0200442).
Breeds in which the phene has been documented. (If a likely causal variant has been documented for the phene, see the variant table breeds in which the variant has been reported).

Cite this entry

Nicholas, F. W., Tammen, I., & Sydney Informatics Hub. (2023). OMIA:001733-9615: Online Mendelian Inheritance in Animals (OMIA) [dataset].


Note: the references are listed in reverse chronological order (from the most recent year to the earliest year), and alphabetically by first author within a year.

2024 Hughes, K., Conaway, E., Blackwell, E., Rout, E., Yoshimoto, J., Burnett, R., Avery, A. :
Canine T zone lymphoma is a tumor of mature, previously activated αβ T cells. Vet Immunol Immunopathol 269:S0165-2427(24)00011-4:110725, 2024. Pubmed reference: 38359755. DOI: 10.1016/j.vetimm.2024.110725.
Jankowska, U., Jagielski, D., Czopowicz, M., Sapierzyński, R. :
Prognostic role of the updated Kiel classification in canine high-grade T-cell lymphomas. Vet Med Sci 10:e1398, 2024. Pubmed reference: 38767567. DOI: 10.1002/vms3.1398.
Messina, M.L., Quintavalla, F., Giannuzzi, A.P., Furlanello, T., Caldin, M. :
An evaluation of hemostatic dysregulation in canine multicentric lymphoma. Animals (Basel) 14:500, 2024. Pubmed reference: 38338143. DOI: 10.3390/ani14030500.
Owens, E., Harris, L., Harris, A., Yoshimoto, J., Burnett, R., Avery, A. :
The gene expression profile and cell of origin of canine peripheral T-cell lymphoma. BMC Cancer 24:18, 2024. Pubmed reference: 38166662. DOI: 10.1186/s12885-023-11762-w.
2023 Bennett, P., Williamson, P., Taylor, R. :
Review of canine lymphoma treated with chemotherapy-outcomes and prognostic cactors. Vet Sci 10:342, 2023. Pubmed reference: 37235425. DOI: 10.3390/vetsci10050342.
Fibi-Smetana, S., Inglis, C., Schuster, D., Eberle, N., Granados-Soler, J.L., Liu, W., Krohn, S., Junghanss, C., Nolte, I., Taher, L., Murua Escobar, H. :
The TiHoCL panel for canine lymphoma: a feasibility study integrating functional genomics and network biology approaches for comparative oncology targeted NGS panel design. Front Vet Sci 10:1301536, 2023. Pubmed reference: 38144469. DOI: 10.3389/fvets.2023.1301536.
Jeong, S.Y. :
Evaluation of factors influencing survival time in 77 dogs with lymphoma. Open Vet J 13:1124-1134, 2023. Pubmed reference: 37842100. DOI: 10.5455/OVJ.2023.v13.i9.8.
Lenz, J.A., Benjamin, S.E., Walsh, K.A., Keuler, N.S., Atherton, M.J. :
Calculation of dose intensity & comparison of published methods using a cohort of canine T-cell lymphoma patients undergoing CHOP-based chemotherapy. Vet Comp Oncol 21:339-348, 2023. Pubmed reference: 36929679. DOI: 10.1111/vco.12894.
Licenziato, L., Minoli, L., Ala, U., Marconato, L., Fanelli, A., Giannuzzi, D., De Maria, R., Iussich, S., Orlando, G., Bertoni, F., Aresu, L. :
Predicting outcome in dogs with diffuse large B-cell lymphoma with a novel immune landscape signature. Vet Pathol 60:308-315, 2023. Pubmed reference: 36951124. DOI: 10.1177/03009858231162209.
Mortlock, S.A., Asada, M.C., Soh, P.X.Y., Hsu, W.T., Lee, C., Bennett, P.F., Taylor, R.M., Khatkar, M.S., Williamson, P. :
Genomic analysis of lymphoma risk in Bullmastiff dogs. Vet Sci 10:703, 2023. Pubmed reference: 38133254. DOI: 10.3390/vetsci10120703.
Oh, J.H., Cho, J.Y. :
Comparative oncology: overcoming human cancer through companion animal studies. Exp Mol Med 55:725-734, 2023. Pubmed reference: 37009802. DOI: 10.1038/s12276-023-00977-3.
Ohmi, A., Tanaka, M., Rinno, J., Tsuboi, M., Chambers, J.K., Uchida, K., Goto-Koshino, Y., Tomiyasu, H., Ohno, K., Tsujimoto, H. :
Clinical characteristics and outcomes of Mott cell lymphoma in nine miniature dachshunds. Vet Med Sci 9:609-617, 2023. Pubmed reference: 36401603. DOI: 10.1002/vms3.975.
Pinello, K., Santos, M., Dias-Pereira, P., Niza-Ribeiro, J., de-Matos, A. :
A retrospective histopathological survey on canine lymphomas subtypes of Porto District. Open Vet J 13:443-450, 2023. Pubmed reference: 37251261. DOI: 10.5455/OVJ.2023.v13.i4.6.
Riccardi, E., Klopfleish, R., Bell, F., Calvez, S.L., Dawson, L.J. :
MUM-1 in canine lymphoma: A pilot study. Vet Pathol 60:316-319, 2023. Pubmed reference: 36800915. DOI: 10.1177/03009858231155401.
Soh, P.X.Y., Khatkar, M.S., Williamson, P. :
Lymphoma in Border Collies: Genome-wide association and pedigree analysis. Vet Sci 10:581, 2023. Pubmed reference: 37756103. DOI: 10.3390/vetsci10090581.
Wade, C.M., Nuttall, R., Liu, S. :
Comprehensive analysis of geographic and breed-purpose influences on genetic diversity and inherited disease risk in the Doberman dog breed. Canine Med Genet 10:7, 2023. Pubmed reference: 37277858. DOI: 10.1186/s40575-023-00130-3.
2021 Hédan, B., Cadieu, É., Rimbault, M., Vaysse, A., Dufaure de Citres, C., Devauchelle, P., Botherel, N., Abadie, J., Quignon, P., Derrien, T., André, C. :
Identification of common predisposing loci to hematopoietic cancers in four dog breeds. PLoS Genet 17:e1009395, 2021. Pubmed reference: 33793571. DOI: 10.1371/journal.pgen.1009395.
2020 Smith, P.A.D., Waugh, E.M., Crichton, C., Jarrett, R.F., Morris, J.S. :
The prevalence and characterisation of TRAF3 and POT1 mutations in canine B-cell lymphoma. Vet J 266:105575, 2020. Pubmed reference: 33323169. DOI: 10.1016/j.tvjl.2020.105575.
2015 Elvers, I., Turner-Maier, J., Swofford, R., Koltookian, M., Johnson, J., Stewart, C., Zhang, C.Z., Schumacher, S.E., Beroukhim, R., Rosenberg, M., Thomas, R., Mauceli, E., Getz, G., Palma, F.D., Modiano, J.F., Breen, M., Lindblad-Toh, K., Alföldi, J. :
Exome sequencing of lymphomas from three dog breeds reveals somatic mutation patterns reflecting genetic background. Genome Res 25:1634-45, 2015. Pubmed reference: 26377837. DOI: 10.1101/gr.194449.115.
Koshino, A., Goto-Koshino, Y., Setoguchi, A., Ohno, K., Tsujimoto, H. :
Mutation of p53 gene and its correlation with the clinical outcome in dogs with lymphoma. J Vet Intern Med 30:223-9, 2015. Pubmed reference: 26678182. DOI: 10.1111/jvim.13807.
2013 Bellumori, T.P., Famula, T.R., Bannasch, D.L., Belanger, J.M., Oberbauer, A.M. :
Prevalence of inherited disorders among mixed-breed and purebred dogs: 27,254 cases (1995-2010). J Am Vet Med Assoc 242:1549-55, 2013. Pubmed reference: 23683021. DOI: 10.2460/javma.242.11.1549.
Dobson, J.M. :
Breed-predispositions to cancer in pedigree dogs. ISRN Vet Sci 2013:941275, 2013. Pubmed reference: 23738139. DOI: 10.1155/2013/941275.
Frantz, A.M., Sarver, A.L., Ito, D., Phang, T.L., Karimpour-Fard, A., Scott, M.C., Valli, V.E., Lindblad-Toh, K., Burgess, K.E., Husbands, B.D., Henson, M.S., Borgatti, A., Kisseberth, W.C., Hunter, L.E., Breen, M., O'Brien, T.D., Modiano, J.F. :
Molecular profiling reveals prognostically significant subtypes of canine lymphoma. Vet Pathol 50:693-703, 2013. Pubmed reference: 23125145. DOI: 10.1177/0300985812465325.
Fujiwara-Igarashi, A., Goto-Koshino, Y., Sato, M., Maeda, S., Igarashi, H., Takahashi, M., Fujino, Y., Ohno, K., Tsujimoto, H. :
Prognostic significance of the expression levels of the p16, p15, and p14 genes in dogs with high-grade lymphoma. Vet J 199:236-44, 2013. Pubmed reference: 24365070. DOI: 10.1016/j.tvjl.2013.11.004.
Thamm, D.H., Grunerud, K.K., Rose, B.J., Vail, D.M., Bailey, S.M. :
DNA repair deficiency as a susceptibility marker for spontaneous lymphoma in golden retriever dogs: a case-control study. PLoS One 8:e69192, 2013. Pubmed reference: 23935952. DOI: 10.1371/journal.pone.0069192.
2012 Tsai, P.C., Breen, M. :
Array-based comparative genomic hybridization-guided identification of reference genes for normalization of real-time quantitative polymerase chain reaction assay data for lymphomas, histiocytic sarcomas, and osteosarcomas of dogs. Am J Vet Res 73:1335-43, 2012. Pubmed reference: 22924713. DOI: 10.2460/ajvr.73.9.1335.
2010 Ponce, F., Marchal, T., Magnol, J.P., Turinelli, V., Ledieu, D., Bonnefont, C., Pastor, M., Delignette, M.L., Fournel-Fleury, C. :
A morphological study of 608 cases of canine malignant lymphoma in France with a focus on comparative similarities between canine and human lymphoma morphology. Vet Pathol 47:414-33, 2010. Pubmed reference: 20472804. DOI: 10.1177/0300985810363902.

Edit History

  • Created by Frank Nicholas on 14 Nov 2012
  • Changed by Imke Tammen2 on 17 Sep 2021
  • Changed by Imke Tammen2 on 07 Jun 2023
  • Changed by Imke Tammen2 on 02 Oct 2023