OMIA:002209-7950 : Adaptation to a red-shifted light environment in Clupea harengus (Atlantic herring) |
Categories: Normal phene
Possibly relevant human trait(s) and/or gene(s) (MIM number): 180380 (gene)
Links to MONDO diseases: No links.
Mendelian trait/disorder: yes
Considered a defect: no
Key variant known: yes
Year key variant first reported: 2019
Molecular basis: Hill et al. (2019): "Atlantic herring . . . colonized the brackish Baltic Sea within the last 10,000 y." Being less salty, the Baltic Sea contains more "dissolved organic matter [that] produces a red-shifted visual environment compared with marine waters." The authors "show that visual adaptation to the new light environment was achieved through a recent and rapid selective sweep on a [missense] mutation [Phe261Tyr] in the rhodopsin gene. Furthermore, this exact same amino acid change has occurred at least 20 separate times in fish species transitioning from marine to brackish or freshwater environments. This is a remarkable example of convergent evolution."
Genetic engineering:
Unknown
Have human generated variants been created, e.g. through genetic engineering and gene editing
Associated gene:
| Symbol | Description | Species | Chr | Location | OMIA gene details page | Other Links |
|---|---|---|---|---|---|---|
| rho | rhodopsin | Clupea harengus | 1 | NC_045152.1 (27341367..27338909) | rho | Homologene, Ensembl , NCBI gene |
Variants
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WARNING! Inclusion of a variant in this table does not automatically mean that it should be used for DNA testing. Anyone contemplating the use of any of these variants for DNA testing should examine critically the relevant evidence (especially in breeds other than the breed in which the variant was first described). If it is decided to proceed, the location and orientation of the variant sequence should be checked very carefully.
Since October 2021, OMIA includes a semiautomated lift-over pipeline to facilitate updates of genomic positions to a recent reference genome position. These changes to genomic positions are not always reflected in the ‘acknowledgements’ or ‘verbal description’ fields in this table.
| OMIA Variant ID | Breed(s) | Variant Phenotype | Gene | Allele | Type of Variant | Source of Genetic Variant | Reference Sequence | Chr. | g. or m. | c. or n. | p. | Verbal Description | EVA ID | Inferred EVA rsID | Year Published | PubMed ID(s) | Acknowledgements |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1099 | Adaptation to a red-shifted light environment | rho | missense | Naturally occurring variant | p.(F261Y) | 2019 | 31451650 |
Cite this entry
Nicholas, F. W., Tammen, I., & Sydney Informatics Hub. (2019). OMIA:002209-7950: Online Mendelian Inheritance in Animals (OMIA) [dataset]. https://omia.org/. https://doi.org/10.25910/2AMR-PV70
Reference
| 2019 | Hill, J., Enbody, E.D., Pettersson, M.E., Sprehn, C.G., Bekkevold, D., Folkvord, A., Laikre, L., Kleinau, G., Scheerer, P., Andersson, L. : |
| Recurrent convergent evolution at amino acid residue 261 in fish rhodopsin. Proc Natl Acad Sci U S A , 2019. Pubmed reference: 31451650. DOI: 10.1073/pnas.1908332116. |
Edit History
- Created by Frank Nicholas on 13 Sep 2019
- Changed by Frank Nicholas on 13 Sep 2019