OMIA:002593-9685 : Cat allergen in Felis catus (domestic cat)

Categories: Normal phene

Mendelian trait/disorder: yes

Considered a defect: no

Key variant known: yes

Year key variant first reported: 2024

Species-specific description: Brackett et al. (2022) "present a bioinformatics analysis of the major cat allergen, Fel d 1, and demonstrate proof of principle for CRISPR gene editing of the allergen." This study involves in vitro CRISPR gene editing (GMO).
Lee et al. (2024) "generated Fel d 1 chain 2 (CH2) genome-edited cats using the CRISPR-Cas9 system ... . ...  ELISA showed that the level of Fel d 1 in the CH2 homozygous genome-edited cat ...  was extremely low compared with that in wild type domestic cats ... . 

Genetic engineering: Yes - variants have been created artificially, e.g. by genetic engineering or gene editing
Have human generated variants been created, e.g. through genetic engineering and gene editing

Clinical features: The cat allergen causes disease in some humans.

Associated gene:

Symbol Description Species Chr Location OMIA gene details page Other Links
CH2 major allergen I, polypeptide chain 2 Felis catus E2 NC_058382.1 (18601998..18599769) CH2 Homologene, Ensembl , NCBI gene

Cite this entry

Nicholas, F. W., Tammen, I., & Sydney Informatics Hub. (2024). OMIA:002593-9685: Online Mendelian Inheritance in Animals (OMIA) [dataset].


Note: the references are listed in reverse chronological order (from the most recent year to the earliest year), and alphabetically by first author within a year.

2024 Lee, S.R., Lee, K.L., Song, S.H., Joo, M.D., Lee, S.H., Kang, J.S., Kang, S.M., Idrees, M., Kim, J.W., Kong, I.K. :
Generation of Fel d 1 chain 2 genome-edited cats by CRISPR-Cas9 system. Sci Rep 14:4987, 2024. Pubmed reference: 38424152. DOI: 10.1038/s41598-024-55464-0.
2023 Bergmann, K.C., Raab, J., Graessel, A., Zwingers, T., Becker, S., Kugler, S., Zuberbier, T., Roth-Walter, F., Kramer, M.F., Jensen-Jarolim, E. :
The holo beta-lactoglobulin lozenge reduces symptoms in cat allergy-Evaluation in an allergen exposure chamber and by titrated nasal allergen challenge. Clin Transl Allergy 13:e12274, 2023. Pubmed reference: 37488734. DOI: 10.1002/clt2.12274.
Trifonova, D., Curin, M., Riabova, K., Karsonova, A., Keller, W., Grönlund, H., Käck, U., Konradsen, J.R., van Hage, M., Karaulov, A., Valenta, R. :
Allergenic activity of individual cat allergen molecules. Int J Mol Sci 24:16729, 2023. Pubmed reference: 38069052. DOI: 10.3390/ijms242316729.
2022 Brackett, N.F., Davis, B.W., Adli, M., Pomés, A., Chapman, M.D. :
Evolutionary biology and gene editing of cat allergen, Fel d 1. CRISPR J 5:213-223, 2022. Pubmed reference: 35343817. DOI: 10.1089/crispr.2021.0101.
Hossenbaccus, L., Linton, S., Ramchandani, R., Burrows, A.G., Ellis, A.K. :
Study of cat allergy using controlled methodology-A review of the literature and a call to action. Front Allergy 3:828091, 2022. Pubmed reference: 35386639. DOI: 10.3389/falgy.2022.828091.
Lyons, L.A. :
It's a knockout for cat allergies? CRISPR J 5:356-357, 2022. Pubmed reference: 35686981. DOI: 10.1089/crispr.2022.29148.lal.
2011 Niespodziana, K., Focke-Tejkl, M., Linhart, B., Civaj, V., Blatt, K., Valent, P., van Hage, M., Grönlund, H., Valenta, R. :
A hypoallergenic cat vaccine based on Fel d 1-derived peptides fused to hepatitis B PreS. J Allergy Clin Immunol 127:1562-70.e6, 2011. Pubmed reference: 21411130. DOI: 10.1016/j.jaci.2011.02.004.
2010 Grönlund, H., Saarne, T., Gafvelin, G., van Hage, M. :
The major cat allergen, Fel d 1, in diagnosis and therapy. Int Arch Allergy Immunol 151:265-74, 2010. Pubmed reference: 19844127. DOI: 10.1159/000250435.
2004 Smith, W., Butler, A.J., Hazell, L.A., Chapman, M.D., Pomés, A., Nickels, D.G., Thomas, W.R. :
Fel d 4, a cat lipocalin allergen. Clin Exp Allergy 34:1732-8, 2004. Pubmed reference: 15544598. DOI: 10.1111/j.1365-2222.2004.02090.x.
2003 Grönlund, H., Bergman, T., Sandström, K., Alvelius, G., Reininger, R., Verdino, P., Hauswirth, A., Liderot, K., Valent, P., Spitzauer, S., Keller, W., Valenta, R., van Hage-Hamsten, M. :
Formation of disulfide bonds and homodimers of the major cat allergen Fel d 1 equivalent to the natural allergen by expression in Escherichia coli. J Biol Chem 278:40144-51, 2003. Pubmed reference: 12732623. DOI: 10.1074/jbc.M301416200.
Liccardi, G., D'Amato, G., Russo, M., Canonica, G.W., D'Amato, L., De Martino, M., Passalacqua, G. :
Focus on cat allergen (Fel d 1): immunological and aerodynamic characteristics, modality of airway sensitization and avoidance strategies. Int Arch Allergy Immunol 132:1-12, 2003. Pubmed reference: 14555853. DOI: 10.1159/000073259.

Edit History

  • Created by Imke Tammen2 on 15 Nov 2022
  • Changed by Imke Tammen2 on 15 Nov 2022
  • Changed by Imke Tammen2 on 18 Dec 2023
  • Changed by Imke Tammen2 on 08 Apr 2024