OMIA:002650-9031 : Egg allergen in Gallus gallus (chicken)

Categories: Normal phene

Mendelian trait/disorder: yes

Considered a defect: no

Key variant known: no

Year key variant first reported: 2023

Species-specific description: Ezaki et al. (2023) report the development of low-allergen eggs by knock out via genome editing of a major egg allergen, ovomucoid (OVM): " we examined the presence or absence of mutant protein expression, vector sequence insertion, and off-target effects in chickens knocked out with OVM by platinum TALENs. The eggs laid by homozygous OVM-knockout hens showed no evident abnormalities, and immunoblotting showed that the albumen contained neither the mature OVM variant nor the OVM truncated variant. Whole genome sequencing (WGS) revealed that the potential TALEN-induced off-target effects in OVM-knockout chickens were localized in the intergenic and intron regions. The WGS information confirmed that plasmid vectors used for genome editing were only transiently present and did not integrate into the genome of edited chickens." This phene includes references to studies involving gene edited or genetically modified organisms (GMO).

Genetic engineering: Yes - variants have been created artificially, e.g. by genetic engineering or gene editing
Have human generated variants been created, e.g. through genetic engineering and gene editing

Clinical features: Egg allergens can cause disease in some humans.

Cite this entry

Nicholas, F. W., Tammen, I., & Sydney Informatics Hub. (2023). OMIA:002650-9031: Online Mendelian Inheritance in Animals (OMIA) [dataset]. https://omia.org/. https://doi.org/10.25910/2AMR-PV70

Reference

2023 Ezaki, R., Sakuma, T., Kodama, D., Sasahara, R., Shiraogawa, T., Ichikawa, K., Matsuzaki, M., Handa, A., Yamamoto, T., Horiuchi, H. :
Transcription activator-like effector nuclease-mediated deletion safely eliminates the major egg allergen ovomucoid in chickens. Food Chem Toxicol 175:113703, 2023. Pubmed reference: 36889429. DOI: 10.1016/j.fct.2023.113703.

Edit History


  • Created by Imke Tammen2 on 10 Mar 2023
  • Changed by Imke Tammen2 on 18 Dec 2023