Pioneers of Mendelian Inheritance in Animals (PMIA)

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2022 Lyons, L.A.
Roy Robinson: tribute from Professor Leslie Lyons.

When I began my post-doctoral fellowship in 1992 at the National Cancer Institute, I knew nothing about the genetics and biology of cats.  The first two books I read were – Roy Robinson’s “Genetics for Cat Breeders” and Paul Leyhausen’s “Cat Behavior”.  These two books established my career goals.  I had to start managing a cat colony, so the cat behavior knowledge was instrumental but Robinson’s book – I set out to help find the genetic cause of everyone of the attributes he presented in his third edition, which was published the year I got my PhD.  A vast majority of the Mendelian coat colors, fur types and a good number of the abnormalities he documented now have known causal DNA variants.  The few that are missing are because the presentations are lost and no DNA samples are available.  I missed meeting Mr. Robinson by a month as I had a trip to the UK the year he passed, I spoke to his window about her loss, our loss.  As I now start to become “long in the tooth” in my cat adventures, I look back and see we have done well in the cat science community over the past 30 years. We have one of the best genomes – telomere to telomere!  Cat breeders can be more efficient with their colony management as a vast majority of the Mendelian coat colors, fur types and morphological traits are known. With a little bit of effort, besides newly acquired sporadic mutations, we could eradicate most Mendelian diseases from the cat fancy.   Precision Medicine is feasible for the random bred, every day house cat.  Although the behaviors depicted by Leyhausen still allude understanding, I think Roy Robinson would be pleased with the cat genetics community.  Thank you Mr. Robinson for the inspiration for my career!  We miss you and speak and think of you often. I hope I have done you proud!  Leslie A. Lyons, PhD 14 December 2022