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OMIA:000033-10160 : Alzheimer-like disease, generic in Octodon degus (degu)

In other species: white-tufted-ear marmoset , crab-eating macaque , Rhesus monkey , hamadryas baboon , dog , domestic cat , saddleback dolphin , long-finned pilot whale , striped dolphin , bottlenosed dolphin , Cuvier's beaked whale , pig , sheep , domestic guinea pig , white-beaked dolphin , northern tree shrew , short-finned pilot whale , Blainville's beaked whale , green monkey , Indo-pacific bottlenose dolphin , Atlantic spotted dolphin , Chinese tree shrew , black-striped capuchin

Categories: Nervous system phene

Links to possible relevant human trait(s) and/or gene(s) in OMIM: 104300 (trait) , 104310 (trait) , 502500 (trait) , 607822 (trait) , 606889 (trait)

Single-gene trait/disorder: unknown

Disease-related: yes

Cross-species summary: renamed from Alzheimer disease, generic to Alzheimer-like disease, generic [20/07/2023].

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Cite this entry

Nicholas, F. W., Tammen, I., & Sydney Informatics Hub. (2013). OMIA:000033-10160: Online Mendelian Inheritance in Animals (OMIA) [dataset]. https://omia.org/. https://doi.org/10.25910/2AMR-PV70

References

Note: the references are listed in reverse chronological order (from the most recent year to the earliest year), and alphabetically by first author within a year.

2025 Hurley, M.J., Garduño, B.M., Deacon, R.M.J., Holmes, T.C., Xu, X., Cogram, P. :
Octodon degus: a natural animal model of aging and Alzheimer's disease. Lab Anim (NY) 54:219-222, 2025. Pubmed reference: 40855196. DOI: 10.1038/s41684-025-01602-8.
Kayano, M. :
Exploring efficient and effective mammalian models for Alzheimer's disease. Front Aging Neurosci 17:1652754, 2025. Pubmed reference: 40893124. DOI: 10.3389/fnagi.2025.1652754.
2024 Garduño, B.M., Holmes, T.C., Deacon, R.M.J., Xu, X., Cogram, P. :
<i>Octodon degus</i> laboratory colony management principles and methods for behavioral analysis for Alzheimer's disease neuroscience research. Front Aging Neurosci 16:1517416, 2024. Pubmed reference: 39902280. DOI: 10.3389/fnagi.2024.1517416.
Zampieri, G., Cabrol, L., Urra, C., Castro-Nallar, E., Schwob, G., Cleary, D., Angione, C., Deacon, R.M.J., Hurley, M.J., Cogram, P. :
Microbiome alterations are associated with apolipoprotein E mutation in Octodon degus and humans with Alzheimer's disease. iScience 27:110348, 2024. Pubmed reference: 39148714. DOI: 10.1016/j.isci.2024.110348.
2012 Ardiles, A.O., Tapia-Rojas, C.C., Mandal, M., Alexandre, F., Kirkwood, A., Inestrosa, N.C., Palacios, A.G. :
Postsynaptic dysfunction is associated with spatial and object recognition memory loss in a natural model of Alzheimer's disease. Proc Natl Acad Sci U S A 109:13835-40, 2012. Pubmed reference: 22869717. DOI: 10.1073/pnas.1201209109.
2011 van Groen, T., Kadish, I., Popović, N., Popović, M., Caballero-Bleda, M., Baño-Otálora, B., Vivanco, P., Rol, M.Á., Madrid, J.A. :
Age-related brain pathology in Octodon degu: blood vessel, white matter and Alzheimer-like pathology. Neurobiol Aging 32:1651-61, 2011. Pubmed reference: 19910078. DOI: 10.1016/j.neurobiolaging.2009.10.008.

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  • Created by Frank Nicholas on 01 Aug 2013