OMIA 000033-9541 : Alzheimer disease in Macaca fascicularis

In other species: dog , degu

Possibly relevant human trait(s) and/or gene(s)s (MIM numbers): 104300 , 104310 , 104311 , 104760 , 163890 , 502500 , 600759

Mendelian trait/disorder: yes

Considered a defect: yes

Key variant known: no

Species-specific description: This animal model of a human disease has been created via transgenic "blastocysts produced by intracytoplasmic sperm injection (ICSI) . . . [being] vitrified and thawed at high efficiency . . . [resulting in] in live births". The resultant animals are, therefore, genetically-modified organisms (GMO).

Associated gene:

Symbol Description Species Chr Location OMIA gene details page Other Links
APP amyloid beta precursor protein Macaca fascicularis 3 NC_022274.1 (20805544..21093823) APP Homologene, Ensembl, NCBI gene

Reference


2020 Seita, Y., Morimura, T., Watanabe, N., Iwatani, C., Tsuchiya, H., Nakamura, S., Suzuki, T., Yanagisawa, D., Tsukiyama, T., Nakaya, M., Okamura, E., Muto, M., Ema, M., Nishimura, M., Tooyama, I. :
Generation of Transgenic Cynomolgus Monkeys Overexpressing the Gene for Amyloid-β Precursor Protein. J Alzheimers Dis :, 2020. Pubmed reference: 32250299. DOI: 10.3233/JAD-191081.

Edit History


  • Created by Frank Nicholas on 08 Apr 2020
  • Changed by Frank Nicholas on 08 Apr 2020