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OMIA:000214-9844 : Coat colour, white spotting in Lama glama (llama)

In other species: dog , domestic cat , horse , taurine cattle , domestic guinea pig , water buffalo

Categories: Pigmentation phene

Possibly relevant human trait(s) and/or gene(s)s (MIM numbers): 193510 (trait) , 103500 (trait) , 156845 (gene)

Links to MONDO diseases: No links.

Mendelian trait/disorder: unknown

Considered a defect: no

Cross-species summary: Variable degree of white spotting ranging from tiny white spots up to completely white animals. The absence of pigment is caused by the absence of skin melanocytes ("leucism, leucistic"), not by failure in the biochemical reactions required for pigment synthesis.

Molecular basis: Anello et al. (2019) reported that although "downregulation of KIT and MITF-M expression is involved in white phenotype production in llamas, the causative gene of white coat color remains unknown."

Genetic engineering: Unknown
Have human generated variants been created, e.g. through genetic engineering and gene editing

Cite this entry

Nicholas, F. W., Tammen, I., & Sydney Informatics Hub. (2019). OMIA:000214-9844: Online Mendelian Inheritance in Animals (OMIA) [dataset]. https://omia.org/. https://doi.org/10.25910/2AMR-PV70

References

Note: the references are listed in reverse chronological order (from the most recent year to the earliest year), and alphabetically by first author within a year.

2020 Jost, S.M., Knoll, A., Lühken, G., Drögemüller, C., Zanolari, P. :
Prevalence of coat colour traits and congenital disorders of South American camelids in Austria, Germany and Switzerland. Acta Vet Scand 62:56, 2020. Pubmed reference: 32948208. DOI: 10.1186/s13028-020-00554-y.
2019 Anello, M., Daverio, M.S., Silbestro, M.B., Vidal-Rioja, L., Di Rocco, F. :
Characterization and expression analysis of KIT and MITF-M genes in llamas and their relation to white coat color. Anim Genet 50:143-149, 2019. Pubmed reference: 30730042. DOI: 10.1111/age.12769.

Edit History


  • Created by Frank Nicholas on 23 Sep 2019
  • Changed by Frank Nicholas on 23 Sep 2019