OMIA:000319-9940 : Ears, folded (drop vs prick) in Ovis aries (sheep)

In other species: dog , domestic cat , pig

Categories: Hearing / vestibular / ear phene

Links to possible relevant human trait(s) and/or gene(s) in OMIM: 113500 (trait) , 606835 (trait) , 606071 (trait) , 156530 (trait) , 168400 (trait) , 181405 (trait) , 184095 (trait) , 600175 (trait) , 184252 (trait) , 605427 (gene) , 613719 (gene) , 613718 (trait) , 617383 (trait)

Mendelian trait/disorder: unknown

Considered a defect: no

Mapping: In the signatures-of-selection analysis of 10 Chinese breeds of sheep, Wei et al. (2015) identified a region on chromosome OAR3 contributing to variation in ear size and hence whether or not ears are floppy. The effect of a SNP within the gene MSRB3 in this region led the authors to conclude that this could be considered as a candidate gene for ear morphology in sheep. Paris et al. (2020) "performed a comprehensive genome‐wide analysis to identify regions under selection for ear morphology in 515 sheep from 17 breeds fixed for diverse ear phenotypes using 34k SNP genotyping data. GWASs for two ear type traits, size and erectness, revealed a single genome‐wide significant association on ovine chromosome 3. The derived marker alleles were enriched in sheep with large and/or floppy ears. The GWAS signal harboured the MSRB3 gene encoding methionine sulphoxide reductase B3, which has already been found to be associated with different ear types in other species. . . . Fine‐mapping suggested that the causal variant for large floppy ears most likely resides in a 175 kb interval downstream of the MSRB3 coding region." Cheng et al. (2023) analysed “whole-genome sequencing individuals of 1,098 domestic sheep from 154 breeds, and 69 wild sheep from seven Ovis species. … several introgressed haplotypes contributed to the morphological differentiations across sheep breeds, … a MSRB3 haplotype from argali strongly associated with ear morphology … .”

Associated gene:

Symbol Description Species Chr Location OMIA gene details page Other Links
MSRB3 methionine sulfoxide reductase B3 Ovis aries 3 NC_056056.1 (154683593..154500209) MSRB3 Homologene, Ensembl , NCBI gene

Cite this entry

Nicholas, F. W., Tammen, I., & Sydney Informatics Hub. (2023). OMIA:000319-9940: Online Mendelian Inheritance in Animals (OMIA) [dataset].


Note: the references are listed in reverse chronological order (from the most recent year to the earliest year), and alphabetically by first author within a year.

2023 Cheng, H., Zhang, Z., Wen, J., Lenstra, J.A., Heller, R., Cai, Y., Guo, Y., Li, M., Li, R., Li, W., He, S., Wang, J., Shao, J., Song, Y., Zhang, L., Billah, M., Wang, X., Liu, M., Jiang, Y. :
Long divergent haplotypes introgressed from wild sheep are associated with distinct morphological and adaptive characteristics in domestic sheep. PLoS Genet 19:e1010615, 2023. Pubmed reference: 36821549. DOI: 10.1371/journal.pgen.1010615.
2020 Paris, J.M., Letko, A., Häfliger, I.M., Ammann, P., Drögemüller, C. :
Ear type in sheep is associated with the MSRB3 locus. Anim Genet 51:968-72, 2020. Pubmed reference: 32805068. DOI: 10.1111/age.12994.
2015 Wei, C., Wang, H., Liu, G., Wu, M., Cao, J., Liu, Z., Liu, R., Zhao, F., Zhang, L., Lu, J., Liu, C., Du, L. :
Genome-wide analysis reveals population structure and selection in Chinese indigenous sheep breeds. BMC Genomics 16:194, 2015. Pubmed reference: 25888314. DOI: 10.1186/s12864-015-1384-9.

Edit History

  • Created by Frank Nicholas on 19 Apr 2020
  • Changed by Frank Nicholas on 19 Apr 2020
  • Changed by Frank Nicholas on 23 Oct 2020
  • Changed by Imke Tammen2 on 25 Feb 2023
  • Changed by Imke Tammen2 on 16 Oct 2023