OMIA 001402-9913 : Multidrug resistance 1, ABCB1-related in Bos taurus

In other species: dog , domestic cat , goat

Category: Homeostasis / metabolism phene

Possibly relevant human trait(s) and/or gene(s)s (MIM numbers): 171050 (gene) , 120080 (trait)

Links to MONDO diseases: No links.

Mendelian trait/disorder: unknown

Considered a defect: yes

Cross-species summary: MDR1

Species-specific description: Seaman et al. (1987) describe "an unusual nervous condition in Murray Grey cattle following treatment with avermectin B1 on a farm in the central tablelands of New South Wales. Eight cattle developed severe signs of central nervous system derangement and died or were euthanased. The neurological syndrome was reproduced in a field trial using avermectin B1. ... The greater than ten-fold concentrations of avermectin B1, detected in the brains of the affected cattle compared to the normal animal suggests an excessively high concentration of the drug in the nervous system of those affected cattle. ... The farm on which the reactions occurred has maintained a virtually closed herd for approximately 15 years. ... It is possible that the affected Murray Greys in this herd had some characteristics that allowed avermectin B, to penetrate the central nervous system more readily than would normally be expected."

Breed: Murray Grey (Cattle) (VBO_0000312).

Reference


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1987 Seaman, J.T., Eagleson, J.S., Carrigan, M.J., Webb, R.F. :
Avermectin B1 toxicity in a herd of Murray Grey cattle. Aust Vet J 64:284-5, 1987. Pubmed reference: 3426470. DOI: 10.1111/j.1751-0813.1987.tb15963.x.

Edit History


  • Changed by Imke Tammen2 on 05 Mar 2021
  • Created by Imke Tammen2 on 05 Mar 2021