OMIA:001402-9925 : Multidrug resistance 1, ABCB1-related in Capra hircus (goat) |
In other species: dog , domestic cat , taurine cattle
Categories: Homeostasis / metabolism phene
Possibly relevant human trait(s) and/or gene(s)s (MIM numbers): 171050 (gene) , 120080 (trait)
Links to MONDO diseases: No links.
Mendelian trait/disorder: unknown
Considered a defect: yes
Cross-species summary: MDR1
Species-specific description: Nürnberger et al. (2021): "a Thuringian goat developed ... neurological signs after treatment with doramectin, a compound from the macrocyclic lactone class. ... For diagnostic purposes, sequencing of the complete mRNA transcript coding for caprine Mdr1 was performed ... . The only position where the Mdr1 sequence from the suspected drug-sensitive goat differed was in the 3'-untranslated region, being a heterozygous single nucleotide polymorphism c.3875C>A. It can be suspected that this variant affects the expression level, stability, or translation efficiency of the Mdr1 mRNA transcript and therefore might be associated with the suspected drug sensitivity."
Genetic engineering:
Unknown
Have human generated variants been created, e.g. through genetic engineering and gene editing
Breed:
Thüringer Wald Ziege, Germany (Goat) (VBO_0009497).
Breeds in which the phene has been documented. For breeds in which a likely causal variant has been documented, see the variant table below
Cite this entry
Nicholas, F. W., Tammen, I., & Sydney Informatics Hub. (2023). OMIA:001402-9925: Online Mendelian Inheritance in Animals (OMIA) [dataset]. https://omia.org/. https://doi.org/10.25910/2AMR-PV70
Reference
2021 | Nürnberger, D., Müller, S.F., Hamann, M., Geyer, J. : |
First sequencing of caprine Mdr1 (Abcb1) mRNA due to suspected neurological adverse drug reaction in a Thuringian goat following extra-label use of doramectin. Front Vet Sci 8:682393, 2021. Pubmed reference: 34169111. DOI: 10.3389/fvets.2021.682393. |
Edit History
- Created by Imke Tammen2 on 01 Jul 2021
- Changed by Imke Tammen2 on 01 Jul 2021
- Changed by Imke Tammen2 on 16 Oct 2023