OMIA:001691-9913 : Recombination rate in Bos taurus (taurine cattle)

In other species: Atlantic salmon , Mallard , chicken , dog , domestic cat , horse , pig , indicine cattle (zebu) , goat , sheep , blackcap

Categories: Normal phene

Links to possible relevant human trait(s) and/or gene(s) in OMIM: 612042 (trait)

Mendelian trait/disorder: no

Mode of inheritance: Multifactorial

Considered a defect: no

Key variant known: no

Mapping: In an imaginative project, Sandor et al. (2012) gathered SNP genotype data from 10,192 Dutch bulls each genotyped with 50,876 SNPs, and 3,783 New Zealand bulls each genotyped with 51,456 SNPs (19,487 SNPs being common to both groups). Each bull belonged to either generation I, II or II of a three-generation pedigree. After phasing the SNP genotypes, Sandor et al. (2012) identified cross-overs in the transmission of gametes from GII bulls to their GIII sons, from which they estimated the genome-wide recombination rate (GRR) for each GII bull. A linkage/LD analysis then revealed two QTL for GRR, one on chromosome BTA10 and another on BTA19. Fine-mapping revealed "genetic variants in REC8 and RNF212 influence genome-wide recombination rate".

Cite this entry

Nicholas, F. W., Tammen, I., & Sydney Informatics Hub. (2013). OMIA:001691-9913: Online Mendelian Inheritance in Animals (OMIA) [dataset].


Note: the references are listed in reverse chronological order (from the most recent year to the earliest year), and alphabetically by first author within a year.

2022 Kadri, N.K., Zhang, J., Oget-Ebrad, C., Wang, Y., Couldrey, C., Spelman, R., Charlier, C., Georges, M., Druet, T. :
High male specific contribution of the X-chromosome to individual global recombination rate in dairy cattle. BMC Genomics 23:114, 2022. Pubmed reference: 35144552. DOI: 10.1186/s12864-022-08328-8.
2020 Zhang, J., Kadri, N.K., Mullaart, E., Spelman, R., Fritz, S., Boichard, D., Charlier, C., Georges, M., Druet, T. :
Genetic architecture of individual variation in recombination rate on the X chromosome in cattle. Heredity (Edinb) 125:304-316, 2020. Pubmed reference: 32651548. DOI: 10.1038/s41437-020-0341-9.
2019 Mouresan, E.F., González-Rodríguez, A., Cañas-Álvarez, J.J., Munilla, S., Altarriba, J., Díaz, C., Baró, J.A., Molina, A., Lopez-Buesa, P., Piedrafita, J., Varona, L. :
Mapping Recombination Rate on the Autosomal Chromosomes Based on the Persistency of Linkage Disequilibrium Phase Among Autochthonous Beef Cattle Populations in Spain. Front Genet 10:1170, 2019. Pubmed reference: 31824571. DOI: 10.3389/fgene.2019.01170.
2016 Kadri, N.K., Harland, C., Faux, P., Cambisano, N., Karim, L., Coppieters, W., Fritz, S., Mullaart, E., Baurain, D., Boichard, D., Spelman, R., Charlier, C., Georges, M., Druet, T. :
Coding and noncoding variants in HFM1, MLH3, MSH4, MSH5, RNF212, and RNF212B affect recombination rate in cattle. Genome Res 26:1323-1332, 2016. Pubmed reference: 27516620. DOI: 10.1101/gr.204214.116.
Wang, Z., Shen, B., Jiang, J., Li, J., Ma, L. :
Effect of sex, age and genetics on crossover interference in cattle. Sci Rep 6:37698, 2016. Pubmed reference: 27892966. DOI: 10.1038/srep37698.
2015 Fröhlich, J., Vozdova, M., Kubickova, S., Cernohorska, H., Sebestova, H., Rubes, J. :
Variation of Meiotic Recombination Rates and MLH1 Foci Distribution in Spermatocytes of Cattle, Sheep and Goats. Cytogenet Genome Res 146:211-21, 2015. Pubmed reference: 26406935. DOI: 10.1159/000439452.
Ma, L., O'Connell, J.R., VanRaden, P.M., Shen, B., Padhi, A., Sun, C., Bickhart, D.M., Cole, J.B., Null, D.J., Liu, G.E., Da, Y., Wiggans, G.R. :
Cattle Sex-Specific Recombination and Genetic Control from a Large Pedigree Analysis. PLoS Genet 11:e1005387, 2015. Pubmed reference: 26540184. DOI: 10.1371/journal.pgen.1005387.
2014 Weng, Z.Q., Saatchi, M., Schnabel, R.D., Taylor, J.F., Garrick, D.J. :
Recombination locations and rates in beef cattle assessed from parent-offspring pairs. Genet Sel Evol 46:34, 2014. Pubmed reference: 24885305. DOI: 10.1186/1297-9686-46-34.
2012 Sandor, C., Li, W., Coppieters, W., Druet, T., Charlier, C., Georges, M. :
Genetic Variants in REC8, RNF212, and PRDM9 Influence Male Recombination in Cattle. PLoS Genet 8:e1002854, 2012. Pubmed reference: 22844258. DOI: 10.1371/journal.pgen.1002854.

Edit History

  • Created by Frank Nicholas on 06 Jan 2013
  • Changed by Frank Nicholas on 22 May 2013