OMIA:002665-9986 : Genetically engineered humanised animal in Oryctolagus cuniculus (rabbit)

In other species: chicken , crab-eating macaque , Rhesus monkey , pig , taurine cattle , goat , sheep , golden hamster

Categories: Immune system phene

Single-gene trait/disorder: unknown

Disease-related: no

Species summary: This entry includes information relating to genetically modified or edited animals that may be used for boppharming. 
FDA approved generation of rabbits engineered to produce recombinant human factor VII (rhFVII), which is used for the treatment of human patients with hemophilia A or B:  https://www.fda.gov/animal-veterinary/biotechnology-products-cvm-animals-and-animal-food/intentional-genomic-alterations-igas-animals

Genetic engineering: Yes - variants have been created artificially, e.g. by genetic engineering or gene editing
Have human generated variants been created, e.g. through genetic engineering and gene editing

Contact us

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Cite this entry

Nicholas, F. W., Tammen, I., & Sydney Informatics Hub. (2025). OMIA:002665-9986: Online Mendelian Inheritance in Animals (OMIA) [dataset]. https://omia.org/. https://doi.org/10.25910/2AMR-PV70

References

Note: the references are listed in reverse chronological order (from the most recent year to the earliest year), and alphabetically by first author within a year.

2026 Zhao, D., Zhao, X., Gao, Y., Yang, S., Guo, X., Zhang, C., Li, C., Zhang, C., Tian, H., Xu, Q., Yin, Z., Liu, Z., Song, J. :
A helicase-fused Cas9 improves large-size fragment knock-in. Mol Ther :S1525-0016(26)00670-2, 2026. Pubmed reference: 42528134. DOI: 10.1016/j.ymthe.2026.07.049.
2025 Fajardo, C., Macedo, M., Buha, T., De Donato, M., Costas, B., Mancera, J.M. :
Genetically modified animal-derived products: From regulations to applications. Animals (Basel) 15:1570, 2025. Pubmed reference: 40509036. DOI: 10.3390/ani15111570.

Edit History


  • Created by Imke Tammen on 17 Jun 2025
  • Changed by Imke Tammen on 17 Jun 2025