OMIA:000344-10036 : Epilepsy in Mesocricetus auratus (golden hamster)

In other species: chicken , white-tufted-ear marmoset , dog , domestic cat , horse , pig , taurine cattle , rabbit , Mongolian gerbil , prairie vole

Categories: Behaviour / neurological phene

Links to possible relevant human trait(s) and/or gene(s) in OMIM: 104130 (trait) , 117100 (trait) , 121200 (trait) , 121201 (trait) , 125370 (trait) , 132090 (trait) , 132100 (trait) , 132300 (trait) , 159600 (trait) , 182610 (trait) , 203600 (trait) , 208700 (trait) , 220300 (trait) , 226750 (trait) , 226800 (trait) , 226810 (trait) , 226850 (trait) , 254770 (trait) , 254780 (trait) , 254800 (trait) , 266270 (trait) , 267740 (trait) , 270805 (trait) , 301900 (trait) , 310370 (trait) , 545000 (trait) , 600131 (trait) , 600143 (trait) , 600512 (trait) , 600513 (trait) , 600669 (trait) , 601068 (trait) , 245570 (trait)

Mendelian trait/disorder: no

Mode of inheritance: Multifactorial

Considered a defect: yes

Key variant known: no

History: As summarised by Muñoz et al. (2017): "The hamster has been previously described as a paroxysmal dystonia model, but our strain is currently recognized as a model of audiogenic seizures (AGS). The original first epileptic hamster appeared spontaneously at the University of Valladolid, where it was known as the GPG:Vall line, and was transferred to the University of Salamanca where a new strain was developed, named GASH:Sal."

Markers: Díaz-Casado et al. (2020) "performed whole exome sequencing (WES) in GASH/Sal animals and their corresponding controls to identify and characterize the mutational landscape of the GASH/Sal strain . . . [from which] 3 high-impact and 15 moderate-impact variants were identified", thereby providing strong evidence of the mutifactorial nature of this disorder. Díaz-Rodríguez et al. (2023) "addressed the influence of the missense single-nucleotide polymorphism (C9586732T, p.His289Tyr) in the glutamate receptor ionotropic kainate-1 (Grik1) gene and its implications for the GASH/Sal seizure susceptibility. ... [The] study reinforces the substantial body of evidence implicating GluK1 receptors in the mechanisms underlying seizures."

Cite this entry

Nicholas, F. W., Tammen, I., & Sydney Informatics Hub. (2024). OMIA:000344-10036: Online Mendelian Inheritance in Animals (OMIA) [dataset]. https://omia.org/. https://doi.org/10.25910/2AMR-PV70

References

Note: the references are listed in reverse chronological order (from the most recent year to the earliest year), and alphabetically by first author within a year.

2023 Bonet-Fernández, J.M., Tranque, P., Aroca-Aguilar, J.D., Muñoz, L.J., López, D.E., Escribano, J., de Cabo, C. :
Seizures regulate the cation-Cl<sup>-</sup> cotransporter NKCC1 in a hamster model of epilepsy: implications for GABA neurotransmission. Front Neurol 14:1207616, 2023. Pubmed reference: 37448751. DOI: 10.3389/fneur.2023.1207616.
Díaz-Rodríguez, S.M., Herrero-Turrión, M.J., García-Peral, C., Gómez-Nieto, R. :
Delving into the significance of the His289Tyr single-nucleotide polymorphism in the glutamate ionotropic receptor kainate-1 (Grik1) gene of a genetically audiogenic seizure model. Front Mol Neurosci 16:1322750, 2023. Pubmed reference: 38249292. DOI: 10.3389/fnmol.2023.1322750.
García-Peral, C., Ledesma, M.M., Herrero-Turrión, M.J., Gómez-Nieto, R., Castellano, O., López, D.E. :
Proteomic and bioinformatic tools to identify potential hub proteins in the audiogenic seizure-prone hamster GASH/Sal. Diagnostics (Basel) 13:1048, 2023. Pubmed reference: 36980356. DOI: 10.3390/diagnostics13061048.
2021 Fuerte-Hortigón, A., Gonçalves, J., Zeballos, L., Masa, R., Gómez-Nieto, R., López, D.E. :
Distribution of the Cannabinoid Receptor Type 1 in the Brain of the Genetically Audiogenic Seizure-Prone Hamster GASH/Sal. Front Behav Neurosci 15:613798, 2021. Pubmed reference: 33841106. DOI: 10.3389/fnbeh.2021.613798.
2020 Díaz-Casado, E., Gómez-Nieto, R., de Pereda, J.M., Muñoz, L.J., Jara-Acevedo, M., López, D.E. :
Analysis of gene variants in the GASH/Sal model of epilepsy. PLoS One 15:e0229953, 2020. Pubmed reference: 32168507. DOI: 10.1371/journal.pone.0229953.
Díaz-Rodríguez, S.M., López-López, D., Herrero-Turrión, M.J., Gómez-Nieto, R., Canal-Alonso, A., Lopéz, D.E. :
Inferior Colliculus Transcriptome After Status Epilepticus in the Genetically Audiogenic Seizure-Prone Hamster GASH/Sal. Front Neurosci 14:508, 2020. Pubmed reference: 32528245. DOI: 10.3389/fnins.2020.00508.
Sánchez-Benito, D., Hyppolito, M.A., Alvarez-Morujo, A.J., López, D.E., Gómez-Nieto, R. :
Morphological and molecular correlates of altered hearing sensitivity in the genetically audiogenic seizure-prone hamster GASH/Sal. Hear Res 392:107973, 2020. Pubmed reference: 32402894. DOI: 10.1016/j.heares.2020.107973.
2017 Barrera-Bailón, B., Oliveira, J.A.C., López, D.E., Muñoz, L.J., Garcia-Cairasco, N., Sancho, C. :
Pharmacological and neuroethological study of the acute and chronic effects of lamotrigine in the genetic audiogenic seizure hamster (GASH:Sal). Epilepsy Behav 71:207-217, 2017. Pubmed reference: 26876275. DOI: 10.1016/j.yebeh.2015.11.005.
López-López, D., Gómez-Nieto, R., Herrero-Turrión, M.J., García-Cairasco, N., Sánchez-Benito, D., Ludeña, M.D., López, D.E. :
Overexpression of the immediate-early genes Egr1, Egr2, and Egr3 in two strains of rodents susceptible to audiogenic seizures. Epilepsy Behav 71:226-237, 2017. Pubmed reference: 26775236. DOI: 10.1016/j.yebeh.2015.12.020.
Muñoz, L.J., Carballosa-Gautam, M.M., Yanowsky, K., García-Atarés, N., López, D.E. :
The genetic audiogenic seizure hamster from Salamanca: The GASH:Sal. Epilepsy Behav 71:181-192, 2017. Pubmed reference: 27072920. DOI: 10.1016/j.yebeh.2016.03.002.
Prieto-Martín, A.I., Aroca-Aguilar, J.D., Sánchez-Sánchez, F., Muñoz, L.J., López, D.E., Escribano, J., de Cabo, C. :
Molecular and neurochemical substrates of the audiogenic seizure strains: The GASH:Sal model. Epilepsy Behav 71:218-225, 2017. Pubmed reference: 26071997. DOI: 10.1016/j.yebeh.2015.05.025.
Sánchez-Benito, D., Gómez-Nieto, R., Hernández-Noriega, S., Murashima, A.A.B., de Oliveira, J.A.C., Garcia-Cairasco, N., López, D.E., Hyppolito, M.A. :
Morphofunctional alterations in the olivocochlear efferent system of the genetic audiogenic seizure-prone hamster GASH:Sal. Epilepsy Behav 71:193-206, 2017. Pubmed reference: 27492627. DOI: 10.1016/j.yebeh.2016.05.040.
2013 Barrera-Bailón, B., Oliveira, J.A., López, D.E., Muñoz, L.J., Garcia-Cairasco, N., Sancho, C. :
Pharmacological and neuroethological studies of three antiepileptic drugs in the Genetic Audiogenic Seizure Hamster (GASH:Sal). Epilepsy Behav 28:413-25, 2013. Pubmed reference: 23872084. DOI: 10.1016/j.yebeh.2013.05.028.
Carballosa-Gonzalez, M.M., Muñoz, L.J., López-Alburquerque, T., Pardal-Fernández, J.M., Nava, E., de Cabo, C., Sancho, C., López, D.E. :
EEG characterization of audiogenic seizures in the hamster strain GASH:Sal. Epilepsy Res 106:318-25, 2013. Pubmed reference: 23916142. DOI: 10.1016/j.eplepsyres.2013.07.001.
2012 Prieto-Martín, A.I., Llorens, S., Pardal-Fernández, J.M., Muñoz, L.J., López, D.E., Escribano, J., Nava, E., de Cabo, C. :
Opposite caudal versus rostral brain nitric oxide synthase response to generalized seizures in a novel rodent model of reflex epilepsy. Life Sci 90:531-7, 2012. Pubmed reference: 22326500. DOI: 10.1016/j.lfs.2012.01.010.
2008 Fuentes-Santamaría, V., Alvarado, J.C., Herranz, A.S., García-Atarés, N., López, D.E. :
Decreased levels of GABA in the inferior colliculus of the epilepsy-prone hamster (GPG/Vall). Epilepsy Res 79:224-7, 2008. Pubmed reference: 18372163. DOI: 10.1016/j.eplepsyres.2008.02.003.
2007 Fuentes-Santamaría, V., Alvarado, J.C., Herranz, A.S., García-Atarés, N., López, D.E. :
Morphologic and neurochemical alterations in the superior colliculus of the genetically epilepsy-prone hamster (GPG/Vall). Epilepsy Res 75:206-19, 2007. Pubmed reference: 17628427. DOI: 10.1016/j.eplepsyres.2007.06.005.
2005 Fuentes-Santamaría, V., Cantos, R., Alvarado, J.C., García-Atarés, N., López, D.E. :
Morphologic and neurochemical abnormalities in the auditory brainstem of the genetically epilepsy-prone hamster (GPG/Vall). Epilepsia 46:1027-45, 2005. Pubmed reference: 16026555. DOI: 10.1111/j.1528-1167.2005.68104.x.

Edit History


  • Created by Frank Nicholas on 31 Oct 2016
  • Changed by Frank Nicholas on 15 Mar 2020
  • Changed by Imke Tammen2 on 23 Jan 2024