OMIA:000683-8932 : Muscular hypertrophy (double muscling) in Columba livia (rock pigeon)

In other species: Japanese flounder , chicken , dog , pig , taurine cattle , goat , sheep , rabbit , water buffalo , Japanese quail , yellow catfish

Categories: Muscle phene

Links to possible relevant human trait(s) and/or gene(s) in OMIM: 601788 (gene) , 614160 (trait)

Links to relevant human diseases in MONDO:

Mendelian trait/disorder: unknown

Considered a defect: no

Cross-species summary: Abnormal increase in muscular tissue caused entirely by enlargement of existing cells (in contrast to muscular hyperplasia, in which the abnormal increase in muscular tissue is due to the formation and growth of new, normal muscle cells)

Mapping: Hou et al. (2023): "The phenotypic data of body weight (BW) and body size (BS) of 556 meat pigeons at 52 and 80 weeks of age were collected. In total, 160 434 high-quality single nucleotide polymorphism sites were obtained by restriction site-associated DNA sequencing. The GWAS analysis revealed that MSTN, IGF2BP3 and NCAPG/LCORL were important candidate genes affecting the growth traits of meat pigeons. ... Phenotypic association validation with the use of two meat pigeon populations found that the MSTN mutation c.C861T [p.(T287T)] determines the MM [muscle mass]."

Associated gene:

Symbol Description Species Chr Location OMIA gene details page Other Links
MSTN myostatin Columba livia 7 NC_088608.1 (27435256..27429655) MSTN Homologene, Ensembl , NCBI gene

Cite this entry

Nicholas, F. W., Tammen, I., & Sydney Informatics Hub. (2024). OMIA:000683-8932: Online Mendelian Inheritance in Animals (OMIA) [dataset].


Note: the references are listed in reverse chronological order (from the most recent year to the earliest year), and alphabetically by first author within a year.

2024 Hou, H., Wang, X., Li, X., Cai, X., Tu, Y., Yang, C., Yao, J. :
Genome-wide association study of growth traits and validation of key mutations (MSTN c.C861T) associated with the muscle mass of meat pigeons. Anim Genet 55:110-122, 2024. Pubmed reference: 38069460. DOI: 10.1111/age.13382.
2019 Liu, H.H., Mao, H.G., Dong, X.Y., Cao, H.Y., Liu, K., Yin, Z.Z. :
Expression of MSTN gene and its correlation with pectoralis muscle fiber traits in the domestic pigeons (Columba livia). Poult Sci 98:5265-5271, 2019. Pubmed reference: 31265735. DOI: 10.3382/ps/pez399.
2013 Dybus, A., Proskura, W.S., Sadkowski, S., Pawlina, E. :
A single nucleotide polymorphism in exon 3 of the myostatin gene in different breeds of domestic pigeon (Columba livia var. domestica). Veterinarni Medicina 58:32–38, 2013.

Edit History

  • Created by Imke Tammen2 on 17 Jan 2024
  • Changed by Imke Tammen2 on 17 Jan 2024