OMIA:000683-9925 : Muscular hypertrophy (double muscling) in Capra hircus (goat)

In other species: Japanese flounder , rock pigeon , chicken , dog , pig , taurine cattle , sheep , rabbit , water buffalo , Japanese quail , yellow catfish

Categories: Muscle phene

Links to possible relevant human trait(s) and/or gene(s) in OMIM: 601788 (gene) , 614160 (trait)

Links to relevant human diseases in MONDO:

Mendelian trait/disorder: yes

Considered a defect: no

Key variant known: no

Cross-species summary: Abnormal increase in muscular tissue caused entirely by enlargement of existing cells (in contrast to muscular hyperplasia, in which the abnormal increase in muscular tissue is due to the formation and growth of new, normal muscle cells)

Species-specific description: This phene includes references to studies involving genetically modified organisms (GMO).

Genetic engineering: Yes - in addition to the occurrence of natural variants, variants have been created artificially, e.g. by genetic engineering or gene editing
Have human generated variants been created, e.g. through genetic engineering and gene editing

Associated gene:

Symbol Description Species Chr Location OMIA gene details page Other Links
MSTN myostatin Capra hircus 2 NC_030809.1 (130232923..130227819) MSTN Homologene, Ensembl , NCBI gene

Cite this entry

Nicholas, F. W., Tammen, I., & Sydney Informatics Hub. (2023). OMIA:000683-9925: Online Mendelian Inheritance in Animals (OMIA) [dataset].


Note: the references are listed in reverse chronological order (from the most recent year to the earliest year), and alphabetically by first author within a year.

2023 Dakhlan, A., Bayu Putra, W.P., Santosa, P.E., Kurniawati, D. :
Novel polymorphisms in caprine myostatin gene and its telationship with growth traits in Saburai does (Capra hircus). Pak J Biol Sci 26:380-385, 2023. Pubmed reference: 37902079. DOI: 10.3923/pjbs.2023.380.385.
Kalds, P., Zhou, S., Huang, S., Gao, Y., Wang, X., Chen, Y. :
When less is more: Targeting the myostatin gene in livestock for augmenting meat production. J Agric Food Chem 71:4216-4227, 2023. Pubmed reference: 36862946. DOI: 10.1021/acs.jafc.2c08583.
2022 Wang, X., Petersen, B. :
More abundant and healthier meat: will the MSTN editing epitome empower the commercialization of gene editing in livestock? Sci China Life Sci 65:448-450, 2022. Pubmed reference: 34431041. DOI: 10.1007/s11427-021-1980-4.
2018 Wang, X., Niu, Y., Zhou, J., Zhu, H., Ma, B., Yu, H., Yan, H., Hua, J., Huang, X., Qu, L., Chen, Y. :
CRISPR/Cas9-mediated MSTN disruption and heritable mutagenesis in goats causes increased body mass. Anim Genet 49:43-51, 2018. Pubmed reference: 29446146. DOI: 10.1111/age.12626.
2014 Singh, S.P., Kumar, R., Kumari, P., Kumar, S., Mitra, A. :
Characterization of 5' upstream region and investigation of TTTTA deletion in 5' UTR of myostatin (MSTN) gene in Indian goat breeds. Anim Biotechnol 25:55-68, 2014. Pubmed reference: 24299184. DOI: 10.1080/10495398.2013.821994.
2013 Zhang, Z.J., Ling, Y.H., Wang, L.J., Hang, Y.F., Guo, X.F., Zhang, Y.H., Ding, J.P., Zhang, X.R. :
Polymorphisms of the myostatin gene (MSTN) and its relationship with growth traits in goat breeds. Genet Mol Res 12:965-71, 2013. Pubmed reference: 23613242. DOI: 10.4238/2013.April.2.12.

Edit History

  • Created by Imke Tammen2 on 28 Aug 2021
  • Changed by Imke Tammen2 on 28 Aug 2021
  • Changed by Imke Tammen2 on 12 Dec 2023