OMIA:001715-9793 : Gaitedness, DMRT3-related in Equus asinus (ass (donkey))

In other species: horse , Przewalski's horse , mule

Categories: Normal phene

Links to possible relevant human trait(s) and/or gene(s) in OMIM: 614754 (gene)

Mendelian trait/disorder: unknown

Considered a defect: no

Cross-species summary: All horses have three naturally occurring gaits, namely (in order of increasing speed) walk (four-beat, lateral), trot (two-beat, diagonal) and gallop (four-beat). Some breeds of horse exhibit more than one form of a particular gait, particularly at intermediate speeds. The alternate forms of intermediate-speed gait are classified as pace (a two-beat gait) or ambling (a four-beat gait), which can be regular (including the Tölt gait of Icelandic horses), lateral or diagonal. Some breeds are four-gaited (e.g. walk, tölt, trot and gallop) and others are five-gaited (e.g. walk, tölt, trot, gallop and pace). "Gaitedness" is the ability to exhibit alternate forms of gait. Gaited breeds included Icelandic horses, Kentucky mountain saddle horse, Missouri fox trotter, Paso fino, Peruvian paso, and Rocky mountain horse, Tennessee walking horse. Non-gaited breeds include Arabian horse, Gotland pony, North-Swedish draft horse, Przewalski’s horse, Shetland pony, Swedish ardennes, Swedish warmblood, and Thoroughbred. (Information taken from Andersson et al., 2012)
Renamed from 'Gaitedness' to 'Gaitedness, DMRT3-related' [10/06/2024]

Species-specific description: Herman et al. (2023) "aimed to determine if genotypes influenced gait type in 159 mules and 203 donkeys genotyped for the DMRT3 SNP by PCR-RFLP analysis. About 47% of mules had the CC-genotype, while 53% had the CA-genotype. Donkeys predominantly had the CC-genotype (97%), and none had AA. Both CC- and CA-genotypes were evenly distributed among mules with the batida or picada gaits. In donkeys, the CC-genotype frequencies were consistent regardless of gait type. However, the CA-genotype was more common in picada-gaited donkeys than in batida-gaited donkeys. ... Contrary to [the authors] expectations, the type of gait, picada or batida, was not influenced by the DMRT3 SNP in the mules or donkeys evaluated."
Bhardwaj et al. (2023) investigated the DMRT3 variant associated with gaitedness in horses (OMIAvariantID:321) in 72 Indian horses' and 33 Indian donkeys' samples. All donkeys were homozygous for the C allele.

Associated gene:

Symbol Description Species Chr Location OMIA gene details page Other Links
DMRT3 doublesex and mab-3 related transcription factor 3 Equus asinus 23 NC_052199.1 (33167783..33153446) DMRT3 Homologene, Ensembl , NCBI gene

Cite this entry

Nicholas, F. W., Tammen, I., & Sydney Informatics Hub. (2024). OMIA:001715-9793: Online Mendelian Inheritance in Animals (OMIA) [dataset]. https://omia.org/. https://doi.org/10.25910/2AMR-PV70

References

Note: the references are listed in reverse chronological order (from the most recent year to the earliest year), and alphabetically by first author within a year.

2023 Herman, M., Caceres, A.M., Albuquerque, A.L.H., Leite, R.O., Araújo, C.E.T., Delfiol, D.J.Z., Curi, R.A., Borges, A.S., Oliveira-Filho, J.P. :
DMRT3 allele frequencies in batida- and picada-gaited donkeys and mules in Brazil. Animals (Basel) 13:3829, 2023. Pubmed reference: 38136866. DOI: 10.3390/ani13243829.
Sonali, Bhardwaj, A,, Unnati, Nayan, V., Legha, R.A., Bhattacharya, T.K., Pal, Y., Giri, S.K. :
Identification and characterization of single nucleotide polymorphisms in DMRT3 gene in Indian horse (Equus caballus) and donkey (Equus asinus) populations. Anim Biotechnol 34:4910-4920, 2023. Pubmed reference: 37149793. DOI: 10.1080/10495398.2023.2206866.

Edit History


  • Created by Imke Tammen2 on 29 Dec 2023
  • Changed by Imke Tammen2 on 04 Jun 2024
  • Changed by Imke Tammen2 on 05 Jun 2024