You are here: OMIA / Search / OMIA:002665 / chicken

OMIA:002665-9031 : Genetically engineered humanised animal in Gallus gallus (chicken)

In other species: crab-eating macaque , Rhesus monkey , pig , taurine cattle , goat , rabbit

Categories: Immune system phene

Single-gene trait/disorder: unknown

Disease-related: unknown

Species summary: Yoo et al. (2024) showed that genome-edited chickens can be an efficient platform for producing multimeric recombinant human adiponectin (ADPN). This study involves genetically modified organisms (GMO).  

Genetic engineering: Yes - variants have been created artificially, e.g. by genetic engineering or gene editing
Have human generated variants been created, e.g. through genetic engineering and gene editing

Contact us

If you notice anything missing or in need of change, please contact us at: [email protected].

Cite this entry

Nicholas, F. W., Tammen, I., & Sydney Informatics Hub. (2024). OMIA:002665-9031: Online Mendelian Inheritance in Animals (OMIA) [dataset]. https://omia.org/. https://doi.org/10.25910/2AMR-PV70

References

Note: the references are listed in reverse chronological order (from the most recent year to the earliest year), and alphabetically by first author within a year.

2025 Fajardo, C., Macedo, M., Buha, T., De Donato, M., Costas, B., Mancera, J.M. :
Genetically modified animal-derived products: From regulations to applications. Animals (Basel) 15:1570, 2025. Pubmed reference: 40509036. DOI: 10.3390/ani15111570.
Fang, M., Chen, X., Liu, Y., Yuan, H. :
Protein production in transgenic chickens mediated through primordial germ cells and embryonic stem cells. Protein Expr Purif 238:106828, 2025. Pubmed reference: 41115512. DOI: 10.1016/j.pep.2025.106828.
2024 Vuong, C.N., Reynolds, K.M., Rivera, G.S., Zeng, B., Karimpourkalou, Z., Norng, M., Zhang, Y., Chowdhury, R., Pedersen, D., Pantoja, M., Collarini, E., Garimalla, S., Izquierdo, S., Vajda, E.G., Antonio, B., Srivastava, D.B., van de Lavoir, M.C., Abdiche, Y., Harriman, W., Leighton, P.A. :
Heavy chain-only antibodies with a stabilized human VH in transgenic chickens for therapeutic antibody discovery. MAbs 16:2435476, 2024. Pubmed reference: 39607037. DOI: 10.1080/19420862.2024.2435476.
Xu, J., Ren, J., Xu, K., Fang, M., Ka, M., Xu, F., Wang, X., Wang, J., Han, Z., Feng, G., Zhang, Y., Hai, T., Li, W., Hu, Z. :
Elimination of GGTA1, CMAH, β4GalNT2 and CIITA genes in pigs compromises human versus pig xenogeneic immune reactions. Animal Model Exp Med 7:584-590, 2024. Pubmed reference: 38962826. DOI: 10.1002/ame2.12461.
Yoo, E., Choi, H.J., Kim, J.K., Kim, Y.M., Park, J.S., Han, J.Y. :
Sustainable production of multimeric and functional recombinant human adiponectin using genome-edited chickens. J Biol Eng 18:32, 2024. Pubmed reference: 38715027. DOI: 10.1186/s13036-024-00427-2.

Edit History


  • Created by Imke Tammen2 on 14 May 2024
  • Changed by Imke Tammen2 on 14 May 2024