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OMIA:002665-9925 : Genetically engineered humanised animal in Capra hircus (goat)

In other species: chicken , crab-eating macaque , Rhesus monkey , pig , taurine cattle , rabbit

Categories: Immune system phene

Single-gene trait/disorder: unknown

Disease-related: no

Species summary: This phene includes references to studies involving gene edited or genetically modified organisms (GMO).

Genetic engineering: Yes - variants have been created artificially, e.g. by genetic engineering or gene editing
Have human generated variants been created, e.g. through genetic engineering and gene editing

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Cite this entry

Nicholas, F. W., Tammen, I., & Sydney Informatics Hub. (2025). OMIA:002665-9925: Online Mendelian Inheritance in Animals (OMIA) [dataset]. https://omia.org/. https://doi.org/10.25910/2AMR-PV70

References

Note: the references are listed in reverse chronological order (from the most recent year to the earliest year), and alphabetically by first author within a year.

2025 Fajardo, C., Macedo, M., Buha, T., De Donato, M., Costas, B., Mancera, J.M. :
Genetically modified animal-derived products: From regulations to applications. Animals (Basel) 15:1570, 2025. Pubmed reference: 40509036. DOI: 10.3390/ani15111570.
Wu, Y., Zheng, J., Chen, J., Sun, T., Luan, T., Li, Y., Fa, Y., Qiu, Y., Zhang, R. :
Optimization of donor structure enhances the generation of cloned goats with high expression of human butyrylcholinesterase by CRISPR/Cas9. Front Bioeng Biotechnol 13:1633553, 2025. Pubmed reference: 41292583. DOI: 10.3389/fbioe.2025.1633553.
2024 Li, D., Guo, R., Chen, F., Wang, J., Wang, F., Wan, Y. :
Genetically engineered goats as efficient mammary gland bioreactors for production of recombinant human neutrophil peptide 1 using CRISPR/Cas9. Biology (Basel) 13:367, 2024. Pubmed reference: 38927247. DOI: 10.3390/biology13060367.
2023 Yan, L., Wu, H., Guan, S., Ma, W., Fu, Y., Ji, P., Lian, Z., Zhang, L., Xing, Y., Wang, B., Liu, G. :
The effects of mammary gland ATIII overexpression on the general health of dairy goats and their anti-inflammatory response to LPS stimulation. Int J Mol Sci 24:15303, 2023. Pubmed reference: 37894983. DOI: 10.3390/ijms242015303.
2009 Lavine, G. :
FDA approves first biological product derived from transgenic animal. Am J Health Syst Pharm 66:518, 2009. Pubmed reference: 19265177. DOI: 10.2146/news090023.
2008 Zou, X., Yuan, S., Xian, J., Zhao, Y., Li, D., Wang, Y., Hao, R., Jie, J., Liu, S., Du, M. :
Large scale production of recombinant human antithrombin Il(rhATI) in transgenic cloned goats. (In Chinese) Chin. J. Biotechnol. 109:117–123, 2008. DOI: 10.13345/j.cjb.2008.01.013.

Edit History


  • Created by Imke Tammen2 on 05 Nov 2023
  • Changed by Imke Tammen2 on 05 Nov 2023
  • Changed by Imke Tammen2 on 10 Dec 2023
  • Changed by Imke Tammen2 on 17 Jun 2025