Gene MSTN : myostatin in Equus caballus

See the equivalent entry at NCBI

In other species: taurine cattle , dog , pig , sheep , chicken , rabbit , goat , water buffalo , Japanese quail , rock pigeon , Japanese flounder

Symbol: MSTN

Description: myostatin

Type of gene: protein-coding

NCBI gene id: 100033832

Other designations: growth/differentiation factor 8|GDF-8

Links: Homologene , Ensembl

Genomic location: 18:66610122..66605150 [Chromosome accession NC_009161.3]

Related phenes:

OMIA:001538-9796 : Racing distance in Equus caballus


Note: the references are listed in reverse chronological order (from the most recent year to the earliest year), and alphabetically by first author within a year.
2016 François, L., Jäderkvist Fegraeus, K., Eriksson, S., Andersson, L.S., Tesfayonas, Y.G., Viluma, A., Imsland, F., Buys, N., Mikko, S., Lindgren, G., Velie, B.D. :
Conformation Traits and Gaits in the Icelandic Horse are Associated with Genetic Variants in Myostatin (MSTN). J Hered 107:431-7, 2016. Pubmed reference: 27208149. DOI: 10.1093/jhered/esw031.
2015 Velie, B.D., Jäderkvist, K., Imsland, F., Viluma, A., Andersson, L.S., Mikko, S., Eriksson, S., Lindgren, G. :
Frequencies of polymorphisms in myostatin vary in Icelandic horses according to the use of the horses. Anim Genet 46:467-8, 2015. Pubmed reference: 26095686. DOI: 10.1111/age.12315.
2014 Dall'Olio, S., Scotti, E., Fontanesi, L., Tassinari, M. :
Analysis of the 227 bp short interspersed nuclear element (SINE) insertion of the promoter of the myostatin (MSTN) gene in different horse breeds. Vet Ital 50:193-7, 2014. Pubmed reference: 25273961. DOI: 10.12834/VetIt.61.178.3.
2013 Li, R., Liu, D.H., Cao, C.N., Wang, S.Q., Dang, R.H., Lan, X.Y., Chen, H., Zhang, T., Liu, W.J., Lei, C.Z. :
Single Nucleotide Polymorphisms of Myostatin gene in Chinese Domestic Horses. Gene 538:150-4, 2013. Pubmed reference: 24368331. DOI: 10.1016/j.gene.2013.12.027.
Petersen, J.L., Mickelson, J.R., Rendahl, A.K., Valberg, S.J., Andersson, L.S., Axelsson, J., Bailey, E., Bannasch, D., Binns, M.M., Borges, A.S., Brama, P., da Câmara Machado, A., Capomaccio, S., Cappelli, K., Cothran, E.G., Distl, O., Fox-Clipsham, L., Graves, K.T., Guérin, G., Haase, B., Hasegawa, T., Hemmann, K., Hill, E.W., Leeb, T., Lindgren, G., Lohi, H., Lopes, M.S., McGivney, B.A., Mikko, S., Orr, N., Penedo, M.C., Piercy, R.J., Raekallio, M., Rieder, S., Røed, K.H., Swinburne, J., Tozaki, T., Vaudin, M., Wade, C.M., McCue, M.E. :
Genome-wide analysis reveals selection for important traits in domestic horse breeds. PLoS Genet 9:e1003211, 2013. Pubmed reference: 23349635. DOI: 10.1371/journal.pgen.1003211.
2012 Baron, E.E., Lopes, M.S., Mendonça, D., da Câmara Machado, A. :
SNP identification and polymorphism analysis in exon 2 of the horse myostatin gene. Anim Genet 43:229-32, 2012. Pubmed reference: 22404361. DOI: 10.1111/j.1365-2052.2011.02229.x.
Bower, M.A., McGivney, B.A., Campana, M.G., Gu, J., Andersson, L.S., Barrett, E., Davis, C.R., Mikko, S., Stock, F., Voronkova, V., Bradley, D.G., Fahey, A.G., Lindgren, G., MacHugh, D.E., Sulimova, G., Hill, E.W. :
The genetic origin and history of speed in the Thoroughbred racehorse. Nat Commun 3:643, 2012. Pubmed reference: 22273681. DOI: 10.1038/ncomms1644.
Hill, E.W., Fonseca, R.G., McGivney, B.A., Gu, J., MacHugh, D.E., Katz, L.M. :
MSTN genotype (g.66493737C/T) association with speed indices in Thoroughbred racehorses. J Appl Physiol 112:86-90, 2012. Pubmed reference: 22016373. DOI: 10.1152/japplphysiol.00793.2011.
Hill, E.W., Ryan, D.P., MacHugh, D.E. :
Horses for courses: a DNA-based test for race distance aptitude in thoroughbred racehorses. Recent Pat DNA Gene Seq 6:203-8, 2012. Pubmed reference: 22845060. DOI: 10.2174/187221512802717277.
McGivney, B.A., Browne, J.A., Fonseca, R.G., Katz, L.M., Machugh, D.E., Whiston, R., Hill, E.W. :
MSTN genotypes in Thoroughbred horses influence skeletal muscle gene expression and racetrack performance. Anim Genet 43:810-2, 2012. Pubmed reference: 22497477. DOI: 10.1111/j.1365-2052.2012.02329.x.
Tozaki, T., Hill, E.W., Hirota, K., Kakoi, H., Gawahara, H., Miyake, T., Sugita, S., Hasegawa, T., Ishida, N., Nakano, Y., Kurosawa, M. :
A cohort study of racing performance in Japanese Thoroughbred racehorses using genome information on ECA18. Anim Genet 43:42-52, 2012. Pubmed reference: 22221024. DOI: 10.1111/j.1365-2052.2011.02201.x.
2011 Tozaki, T., Sato, F., Hill, E.W., Miyake, T., Endo, Y., Kakoi, H., Gawahara, H., Hirota, K., Nakano, Y., Nambo, Y., Kurosawa, M. :
Sequence variants at the myostatin gene locus influence the body composition of Thoroughbred horses. J Vet Med Sci 73:1617-24, 2011. Pubmed reference: 21836385. DOI: 10.1292/jvms.11-0295.
2010 Binns, MM., Boehler, DA., Lambert, DH. :
Identification of the myostatin locus (MSTN) as having a major effect on optimum racing distance in the Thoroughbred horse in the USA. Anim Genet 41 Suppl 2:154-8, 2010. Pubmed reference: 21070290. DOI: 10.1111/j.1365-2052.2010.02126.x.
Dall'Olio, S., Fontanesi, L., Nanni Costa, L., Tassinari, M., Minieri, L., Falaschini, A. :
Analysis of horse myostatin gene and identification of single nucleotide polymorphisms in breeds of different morphological types. J Biomed Biotechnol 2010, 2010. Pubmed reference: 20706663. DOI: 10.1155/2010/542945.
Hill, E.W., Gu, J., Eivers, S.S., Fonseca, R.G., McGivney, B.A., Govindarajan, P., Orr, N., Katz, L.M., MacHugh, D.E., MacHugh, D. :
A sequence polymorphism in MSTN predicts sprinting ability and racing stamina in thoroughbred horses. PLoS One 5:e8645, 2010. Pubmed reference: 20098749. DOI: 10.1371/journal.pone.0008645.
Hill, E.W., McGivney, B.A., Gu, J., Whiston, R., Machugh, D.E. :
A genome-wide SNP-association study confirms a sequence variant (g.66493737C>T) in the equine myostatin (MSTN) gene as the most powerful predictor of optimum racing distance for Thoroughbred racehorses. BMC Genomics 11:552, 2010. Pubmed reference: 20932346. DOI: 10.1186/1471-2164-11-552.