Gene MSTN : myostatin in Bos taurus

See the equivalent entry at NCBI

In other species: dog , pig , sheep , chicken , horse , rabbit , goat , water buffalo , Japanese quail , rock pigeon , Japanese flounder

Symbol: MSTN

Synonyms: GDF8

Description: myostatin

Type of gene: protein-coding

NCBI gene id: 281187

Other designations: growth/differentiation factor 8|GDF-8

Links: Homologene , Ensembl

Genomic location: 2:6278864..6285491 [Chromosome accession NC_037329.1]

Related phenes:

OMIA:000683-9913 : Muscular hypertrophy (double muscling) in Bos taurus


Note: the references are listed in reverse chronological order (from the most recent year to the earliest year), and alphabetically by first author within a year.
2015 Proudfoot, C., Carlson, D.F., Huddart, R., Long, C.R., Pryor, J.H., King, T.J., Lillico, S.G., Mileham, A.J., McLaren, D.G., Whitelaw, C.B., Fahrenkrug, S.C. :
Genome edited sheep and cattle. Transgenic Res 24:147-53, 2015. Pubmed reference: 25204701. DOI: 10.1007/s11248-014-9832-x.
Zhao, L.H., Zhao, Y.H., Liang, H., Yun, T., Han, X.J., Zhang, M.L., Zhou, X., Hou, D.X., Li, R.F., Li, X.L. :
A promoter trap vector for knocking out bovine myostatin gene with high targeting efficiency. Genet Mol Res 14:2750-61, 2015. Pubmed reference: 25867424. DOI: 10.4238/2015.March.31.5.
2014 Yang, C., Tong, H., Ma, X., Du, W., Liu, D., Yang, Y., Yan, Y. :
Myostatin knockout in bovine fetal fibroblasts by using TALEN. Yi Chuan 36:685-90, 2014. Pubmed reference: 25076033. DOI: 10.3724/SP.J.1005.2014.0685.
2013 Druet, T., PĂ©rez-Pardal, L., Charlier, C., Gautier, M. :
Identification of large selective sweeps associated with major genes in cattle. Anim Genet 44:758-62, 2013. Pubmed reference: 23859468. DOI: 10.1111/age.12073.
O'Rourke, B.A., Greenwood, P.L., Arthur, P.F., Goddard, M.E. :
Inferring the recent ancestry of myostatin alleles affecting muscle mass in cattle. Anim Genet 44:86-90, 2013. Pubmed reference: 22497537. DOI: 10.1111/j.1365-2052.2012.02354.x.
Xu, L., Zhao, P., Mariano, A., Han, R. :
Targeted Myostatin Gene Editing in Multiple Mammalian Species Directed by a Single Pair of TALE Nucleases. Mol Ther Nucleic Acids 2:e112, 2013. Pubmed reference: 23900226. DOI: 10.1038/mtna.2013.39.
1997 Kambadur, R., Sharma, M., Smith, T.P.L., Bass, J.J. :
Mutations in myostatin (GDF8) in double-muscled Belgian Blue and Piedmontese cattle Genome Res 7:910-6, 1997. Pubmed reference: 9314496. DOI: 10.1101/gr.7.9.910.
McPherron, A.C., Lee, S.J. :
Double muscling in cattle due to mutations in the myostatin gene Proc Natl Acad Sci U S A 94:12457-61, 1997. Pubmed reference: 9356471. DOI: 10.1073/pnas.94.23.12457.