OMIA 000201-37029 : Coat colour, agouti in Prionailurus bengalensis

In other species: horse , cattle , meadow voles , red fox , pig , sheep , domestic cat , rabbit , dog , gray wolf , coyote , goat , Eurasian water mole , Northern mole vole , North American deer mouse , alpaca , leopard , Asiatic golden cat , ass , impala , Colocolo , Kodkod , Arabian camel , Mongolian gerbil , domestic guinea pig , Western roe deer

Possibly relevant human trait(s) and/or gene(s)s (MIM numbers): 611742 (trait) , 600201 (gene)

Mendelian trait/disorder: yes

Mode of inheritance: Autosomal Incompletely Dominant

Considered a defect: no

Key variant known: yes

Year key variant first reported: 2014

Cross-species summary: This locus, ASIP, encodes the agouti signalling protein, a peptide antagonist of the melanocyte-stimulating hormone receptor (MC1R), which is the product of the extension locus. As explained by Schneider et al. (PLoS Genet 10(2): e1004892; 2015), "The most common causes of melanism (black coat) mutations are gain-of-function alterations in MC1R, or loss-of function alterations in ASIP, which encodes Agouti signaling protein, a paracrine signaling molecule that inhibits MC1R signaling".

Species-specific description: "The Bengal cat breed consists of hybrid animals developed from crosses between the domestic cat (Felis silvestris catus) and the Asian leopard cat (Prionailurus bengalensis)" (Gershony et al., 2014)

Molecular basis: By sequencing a prime comparative candidate locus (ASIP) in Bengal cats, Asian leopard cats and domestic cats, Gershony et al. (2014) showed that the charcoal coat colouration/pattern in Bengal cats is strongly associated with heterozygosity for an ASIP haplotye from the euptilura form of Asian leopard cat (called A^Pbe) and the classic non-agouti alllele (a; see OMIA 000201-9685) from domestic cats. The A^Pbe allele, considered by Gershony et al. (2014) to be the wild-type ASIP allele in euptilura Asian leopard cats, differs from the non-agouti a allele as follows: c.41G>C; absence of c.123-124 2-bp del; c.142T>C; c.251A>G; and C.302 A>G.

Breed: Bengal.

Associated gene:

Symbol Description Species Chr Location OMIA gene details page Other Links
ASIP Prionailurus bengalensis - no genomic information (-..-) ASIP Ensembl


2014 Gershony, L.C., Penedo, M.C., Davis, B.W., Murphy, W.J., Helps, C.R., Lyons, L.A. :
Who's behind that mask and cape? The Asian leopard cat's Agouti (ASIP) allele likely affects coat colour phenotype in the Bengal cat breed. Anim Genet :, 2014. Pubmed reference: 25143047. DOI: 10.1111/age.12206.

Edit History

  • Created by Frank Nicholas on 03 Oct 2014
  • Changed by Frank Nicholas on 03 Oct 2014