OMIA:000201-10053 : Coat colour, agouti in Microtus (meadow voles)
In other species: gray wolf , coyote , dog , red fox , domestic cat , leopard , ass (donkey) , horse , pig , Arabian camel , llama , Western roe deer , impala , taurine cattle , goat , sheep , rabbit , North American deer mouse , Mongolian gerbil , domestic guinea pig , alpaca , leopard cat , oldfield mouse , Kodkod , Colocolo , Asiatic golden cat , Northern mole vole , Eurasian water mole
Categories: Pigmentation phene
Links to MONDO diseases: No links.
Mendelian trait/disorder: yes
Considered a defect: no
Key variant known: no
Cross-species summary: This locus, ASIP, encodes the agouti signalling protein, a peptide antagonist of the melanocyte-stimulating hormone receptor (MC1R), which is the product of the extension locus. As explained by Schneider et al. (PLoS Genet 10(2): e1004892; 2015), "The most common causes of melanism (black coat) mutations are gain-of-function alterations in MC1R, or loss-of function alterations in ASIP, which encodes Agouti signaling protein, a paracrine signaling molecule that inhibits MC1R signaling".
Have human generated variants been created, e.g. through genetic engineering and gene editing
Cite this entry
Note: the references are listed in reverse chronological order (from the most recent year to the earliest year), and alphabetically by first author within a year.
|1996||Bazhan, N.M., Yakovleva, T.V., Makarova, E.N. :|
|Reproduction in the water vole (arvicola terrestris), polymorphic for the agouti locus [Russian] Genetika 32:1125-1130, 1996. Pubmed reference: 8964483.|
|1991||Prasolova, L.A., Bazhan, N.M., Vsevolodov, E.B., Latypov, I.F. :|
|[Verification of the color genotype based on morphological analysis of fur pigmentation of brown and black water voles Arvicola terrestris L]. Genetika 27:1423-30, 1991. Pubmed reference: 1761214.|
- Created by Frank Nicholas on 06 Sep 2005
- Changed by Frank Nicholas on 23 Oct 2011