OMIA 000201 : Coat colour, agouti

Possible human homologues (MIM numbers): 611742 (trait) , 600201 (gene)

Cross-species summary: This locus, ASIP, encodes the agouti signalling protein, a peptide antagonist of the melanocyte-stimulating hormone receptor (MC1R), which is the product of the extension locus. As explained by Schneider et al. (PLoS Genet 10(2): e1004892; 2015), "The most common causes of melanism (black coat) mutations are gain-of-function alterations in MC1R, or loss-of function alterations in ASIP, which encodes Agouti signaling protein, a paracrine signaling molecule that inhibits MC1R signaling".

Species in which this phene is found:
gray wolf (Canis lupus)
coyote (Canis latrans)
dog (Canis lupus familiaris)
red fox (Vulpes vulpes)
domestic cat (Felis catus)
leopard (Panthera pardus)
ass (Equus asinus)
horse (Equus caballus)
pig (Sus scrofa)
Arabian camel (Camelus dromedarius)
Western roe deer (Capreolus capreolus)
impala (Aepyceros melampus)
cattle (Bos taurus)
goat (Capra hircus)
sheep (Ovis aries)
rabbit (Oryctolagus cuniculus)
North American deer mouse (Peromyscus maniculatus)
Mongolian gerbil (Meriones unguiculatus)
meadow voles (Microtus)
domestic guinea pig (Cavia porcellus)
alpaca (Vicugna pacos)
leopard cat (Prionailurus bengalensis)
Kodkod (Leopardus guigna)
Colocolo (Leopardus colocolo)
Asiatic golden cat (Catopuma temminckii)
Northern mole vole (Ellobius talpinus)
Eurasian water mole (Arvicola amphibius)

Edit History


  • Created by Frank Nicholas on 03 May 2005
  • Changed by Frank Nicholas on 12 Oct 2011
  • Changed by Frank Nicholas on 18 Sep 2012
  • Changed by Frank Nicholas on 06 May 2019
  • Changed by Frank Nicholas on 31 Mar 2020
  • Changed by Imke Tammen2 on 06 Jul 2021