OMIA 000201-9614 : Coat colour, agouti in Canis latrans

In other species: horse , cattle , meadow voles , red fox , pig , sheep , domestic cat , rabbit , dog , gray wolf , goat , Eurasian water mole , Northern mole vole , North American deer mouse , alpaca , leopard , Asiatic golden cat , leopard cat , ass , impala , Colocolo , Kodkod , Arabian camel , Mongolian gerbil , domestic guinea pig , Western roe deer

Possibly relevant human trait(s) and/or gene(s)s (MIM numbers): 611742 (trait) , 600201 (gene)

Mendelian trait/disorder: yes

Considered a defect: no

Key variant known: no

Cross-species summary: This locus, ASIP, encodes the agouti signalling protein, a peptide antagonist of the melanocyte-stimulating hormone receptor (MC1R), which is the product of the extension locus. As explained by Schneider et al. (PLoS Genet 10(2): e1004892; 2015), "The most common causes of melanism (black coat) mutations are gain-of-function alterations in MC1R, or loss-of function alterations in ASIP, which encodes Agouti signaling protein, a paracrine signaling molecule that inhibits MC1R signaling".

Molecular basis: Schmutz et al. (2007) documented polymorphisms in the ASIP gene of wolves and coyotes, some of which are shared by dogs.

Reference


2007 Schmutz, SM., Berryere, TG., Barta, JL., Reddick, KD., Schmutz, JK. :
Agouti sequence polymorphisms in coyotes, wolves and dogs suggest hybridization. J Hered 98:351-5, 2007. Pubmed reference: 17630272. DOI: 10.1093/jhered/esm036.

Edit History


  • Created by Frank Nicholas on 20 Nov 2010
  • Changed by Frank Nicholas on 12 Sep 2011
  • Changed by Frank Nicholas on 12 Oct 2011
  • Changed by Frank Nicholas on 12 Dec 2011
  • Changed by Frank Nicholas on 21 Mar 2012
  • Changed by Frank Nicholas on 21 Jun 2013