OMIA:000201-9614 : Coat colour, agouti in Canis latrans (coyote)
In other species: gray wolf , dog , red fox , domestic cat , leopard , ass (donkey) , horse , pig , Arabian camel , llama , Western roe deer , impala , taurine cattle , goat , sheep , rabbit , North American deer mouse , Mongolian gerbil , meadow voles , domestic guinea pig , alpaca , leopard cat , oldfield mouse , Kodkod , Colocolo , Asiatic golden cat , Northern mole vole , Eurasian water mole
Categories: Pigmentation phene
Links to MONDO diseases: No links.
Mendelian trait/disorder: yes
Considered a defect: no
Key variant known: no
Cross-species summary: This locus, ASIP, encodes the agouti signalling protein, a peptide antagonist of the melanocyte-stimulating hormone receptor (MC1R), which is the product of the extension locus. As explained by Schneider et al. (PLoS Genet 10(2): e1004892; 2015), "The most common causes of melanism (black coat) mutations are gain-of-function alterations in MC1R, or loss-of function alterations in ASIP, which encodes Agouti signaling protein, a paracrine signaling molecule that inhibits MC1R signaling".
Molecular basis: Schmutz et al. (2007) documented polymorphisms in the ASIP gene of wolves and coyotes, some of which are shared by dogs.
Have human generated variants been created, e.g. through genetic engineering and gene editing
Cite this entry
|2007||Schmutz, SM., Berryere, TG., Barta, JL., Reddick, KD., Schmutz, JK. :|
|Agouti sequence polymorphisms in coyotes, wolves and dogs suggest hybridization. J Hered 98:351-5, 2007. Pubmed reference: 17630272. DOI: 10.1093/jhered/esm036.|
- Created by Frank Nicholas on 20 Nov 2010
- Changed by Frank Nicholas on 12 Sep 2011
- Changed by Frank Nicholas on 12 Oct 2011
- Changed by Frank Nicholas on 12 Dec 2011
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- Changed by Frank Nicholas on 21 Jun 2013